{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:45:57Z","timestamp":1782618357319,"version":"3.54.5"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Radiotherapy causes significant nasal comorbidity in nasopharynx cancer (NPC) patients. However, the literature addressing the sino-nasal quality of life (QoL) of those patients, especially on structural and functional changes after radiotherapy, is limited.\n                    <jats:bold>Method:<\/jats:bold>\n                    It is a case-control study with 14 NPC groups and 14 healthy control group. The sino-nasal QoL, including the olfactory threshold using Butanol Threshold Test (BTT), the olfactory identification level using the University of Pennsylvania Smell Identification Test (UPSIT), nasal symptoms using the sino-nasal outcome test (SNOT-22) questionnaire, nasal cross-sectional area, nasal flow, and nasal resistance using the acoustic rhinometry and rhinomanometry, were measured and compared.\n                    <jats:bold>Result:<\/jats:bold>\n                    The mean BTT score of the control group was higher than that of the NPC group (5.17 vs 2.71). The UPSIT score of the control group was higher than that of the NPC group (31.93 vs 25.14). The mean SNOT-22 score of control group was lower than that of the NPC group of (16.71 vs 37.71). All 3 results are statistically significant (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). However, there is no statistical difference in nasal cross-sectional area, nasal flow, and nasal resistance between these 2 groups.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    In this study, we concluded that NPC patients who received radiotherapy suffered a worsening of sino-nasal functional changes, including the olfaction threshold, olfaction identification, and nasal symptoms. However, the sino-nasal structural changes on nasal cross-sectional area, nasal flow, and nasal resistance after radiation remain questionable.\n                  <\/jats:p>","DOI":"10.1177\/01455613231204210","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T04:26:06Z","timestamp":1700713566000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Radiotherapy on Sino-nasal Function in Nasopharynx Cancer Patients"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-2479","authenticated-orcid":false,"given":"Fergus Kai-Chuen","family":"Wong","sequence":"first","affiliation":[{"name":"Department of ENT, Pamela Youde Nethersole Eastern Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin Chun-Yin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin Po-Ngai","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of ENT, Pamela Youde Nethersole Eastern Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5256-1915","authenticated-orcid":false,"given":"Peter Ka-Chung","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of ENT, Pamela Youde Nethersole Eastern Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Man","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of ENT, Pamela Youde Nethersole Eastern Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.12.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.702"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.022"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.10.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21575"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23849"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198801000-00017"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(84)90269-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.08.013"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26634"},{"issue":"77","key":"e_1_3_3_12_2","first-page":"211","article-title":"Assessment of olfactory threshold in patients undergoing radiotherapy for head and neck malignancies","volume":"26","author":"Jalali MM","year":"2014","unstructured":"Jalali MM, Gerami H, Rahimi A, Jafari M. Assessment of olfactory threshold in patients undergoing radiotherapy for head and neck malignancies. Iran J Otorhinolaryngol. 2014;26(77):211-217.","journal-title":"Iran J Otorhinolaryngol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102537"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2014.02.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410018106"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.HTR.0000341437.59627.ec"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino16.195"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11060686"},{"key":"e_1_3_3_19_2","unstructured":"Hong Kong Cancer Registry HA. Overview of HK Cancer Stat 2019. Accessed February 16 2022. https:\/\/www3.ha.org.hk\/cancereg\/pdf\/overview\/Overview%20of%20HK%20Cancer%20Stat%202019.pdf"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613231204210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613231204210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613231204210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:23:05Z","timestamp":1782616985000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613231204210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/01455613231204210"],"URL":"https:\/\/doi.org\/10.1177\/01455613231204210","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]}}}