{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:45:56Z","timestamp":1782618356328,"version":"3.54.5"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"research of Shanghai Pudong District Health Commission","award":["PW2022A-41"],"award-info":[{"award-number":["PW2022A-41"]}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20214Y0025"],"award-info":[{"award-number":["20214Y0025"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The objective of this study is to assess the risk factors for synchronous lung metastases (LM) in patients with hypopharynx squamous cell carcinomas (HPSCC).\n                    <jats:bold>Methods:<\/jats:bold>\n                    HPSCC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2013. We examined the association between risk factors and synchronous LM using chi-squared tests. Predictors of survival rates were assessed using univariate and multivariate analyses.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 1683 patients were analyzed, including 70 patients (4.2%) with synchronous LM, and 1613 patients without synchronous LM (95.8%). Multivariate logistic regression analysis showed that Caucasian (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.038), lower T (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.026) or N classification (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.000), and highly differentiated disease (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.002) were associated with a significantly lower risk of LM. Elderly not married patients with higher T or N classification, multiple sites of metastases, and no surgical therapy to the primary tumors were more likely to reduce life expectancy.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    By analyzing data from a large cohort, Caucasian, lower T or N classification, and highly differentiated disease were associated with a significantly lower risk of LM. Elderly not married patients with advanced T or N classification, no surgical therapy to the primary tumors, and multiple sites of metastases were more likely to reduce life expectancy. More accurate assessments of LM will be imperative for early diagnosis and treatment in non-Caucasian patients who harbored higher T or N classification and poorly differentiated disease.\n                  <\/jats:p>","DOI":"10.1177\/01455613231212052","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T07:27:34Z","timestamp":1700638054000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Synchronous Lung Metastasis in Squamous Cell Carcinoma of Hypopharynx"],"prefix":"10.1177","volume":"105","author":[{"given":"Yujiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Cancer Hospital, Shanghai, China"},{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China"},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China"},{"name":"Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-8180","authenticated-orcid":false,"given":"Chaosu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Cancer Hospital, Shanghai, China"},{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, China"},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China"},{"name":"Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China"},{"name":"Department of Oncology, Shanghai Medical College, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21384"},{"key":"e_1_3_2_3_2","first-page":"1","article-title":"Epidemiology of hypopharyngeal cancer","volume":"83","author":"Bradley PJ.","year":"2019","unstructured":"Bradley PJ. Epidemiology of hypopharyngeal cancer. Adv Otorhinolaryngol. 2019;83:1-14.","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21613"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31294"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14059"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-013-9630-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.14735\/amko2019294"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24687"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.28554"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.03.013"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.11.023"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06118-0"},{"issue":"11","key":"e_1_3_2_14_2","first-page":"2467","article-title":"Impact of race on outcome after definitive radiotherapy for squamous cell carcinoma of the head and neck","volume":"98","author":"Al-Othman MOF","year":"2003","unstructured":"Al-Othman MOF, Morris CG, Logan HL, et al. Impact of race on outcome after definitive radiotherapy for squamous cell carcinoma of the head and neck. 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