{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:45:58Z","timestamp":1782618358006,"version":"3.54.5"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    We aim to provide an overview of the clinical characteristics and treatment of pediatric acute mastoiditis (AM) and its complications in the prevaccinal pneumococcal period.\n                    <jats:bold>Materials and methods:<\/jats:bold>\n                    Retrospective case series. An analysis of pediatric patients with AM treated at a university tertiary care center from 2008 to 2018 was performed.\n                    <jats:bold>Results:<\/jats:bold>\n                    The research included 121 children, and 27.3% of them had some form of complication. The mean age at presentation of AM was 3.7\u2009years (range\u2009=\u20090\u201318\u2009years). The most common extracranial complication of AM was a subperiosteal abscess (n\u2009=\u200925, 75.8%) and the most common intracranial complication was meningoencephalitis (n\u2009=\u20092, 6%). The most common pathogen isolated in the complicated AM was\n                    <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                    (n\u2009=\u200917, 51.5%). A total of 60% of patients reported antibiotic use before hospital admission, mostly third-generation cephalosporins (37.5%). There was a statistically significant difference between age group and occurrence of complications (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.001). Females had complications more frequently than males (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.035). There were no statistically significant differences in levels of inflammatory parameters (C-reactive protein and leukocyte count) between patients with or without complications (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.373 and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.124; respectively). All patients with complications of AM were surgically treated. Mortality was 0% and all children completely recovered.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Extracranial and intracranial complications of AM required surgical treatment and extended antibiotic therapy. Inflammation parameters did not have a predictive role in identifying children with complications of AM. Further investigations will determine whether the introduction of the mandatory pneumococcal vaccine in our country has led to a reduction in the incidence of AM and its complications.\n                  <\/jats:p>","DOI":"10.1177\/01455613231212828","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T03:56:10Z","timestamp":1700798170000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Treatment Experiences of Pediatric Acute Mastoiditis and Its Complications at the University Tertiary Care Center in the 10-Year Prevaccinal Period"],"prefix":"10.1177","volume":"105","author":[{"given":"Ljiljana","family":"Cvorovic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Centre Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Dudvarski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Centre Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-476X","authenticated-orcid":false,"given":"Nenad","family":"Relic","sequence":"additional","affiliation":[{"name":"Clinic for Otorhinolaryngology, University Clinical Centre Kragujevac, Kragujevac, Serbia"},{"name":"Department of Otorhinolaryngology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nemanja","family":"Radivojevic","sequence":"additional","affiliation":[{"name":"Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Centre Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Soldatovic","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Statistics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Arsovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Centre Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992280404300307"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3349"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-018-0511-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.07.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2010.09.013"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599821989633"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000920"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.11.002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31817f736b"},{"issue":"1","key":"e_1_3_2_12_2","first-page":"54","article-title":"Acute mastoiditis in children","volume":"91","author":"Cassano P","year":"2020","unstructured":"Cassano P, Ciprandi G, Passali D. Acute mastoiditis in children. Acta Biomed. 2020;91(1-S):54-59. 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