{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:54:00Z","timestamp":1790650440151,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Preceptis Medical"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    <jats:bold>Importance:<\/jats:bold>\n                    Phenol kits cleared by the Food and Drug Administration (FDA) are indicated as a topical anesthetic for the tympanic membrane (TM) in adults. However, there is no existing literature that reports outcomes to support the safety and use of phenol on the TM of awake children.\n                    <jats:bold>Objective:<\/jats:bold>\n                    Determine if topical phenol is safe and at low risk for complications and therefore be used effectively in awake children to facilitate office otologic procedures as in adults.\n                    <jats:bold>Design, Setting, and Participants:<\/jats:bold>\n                    Children under 21\u2009years of age whose parents agreed to participate in an awake office setting for tympanostomy tube (TT) placement. All children had TT placement after phenol placement on the TM prior to insertion.\n                    <jats:bold>Main Outcomes and Measures:<\/jats:bold>\n                    TM perforation or other signs of TM complications through a minimum of 6-month clinical follow-up, along with assessment of the tolerability of the procedure by the child.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 228 children with an age range of 6\u2009months to 15.9\u2009years and 435 TMs completed TT placement using phenol as a local anesthetic while awake in the office. There were no complications reported in the 204 children at the first follow-up visit post TM placement within 3 to 10\u2009weeks. Of the 93 children followed up at least 6\u2009months, there were no TM complications reported.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This is the first study to report the outcomes on the use of phenol in an office setting in children. In this large experience, phenol appears to be tolerable and safe for use in young children in the office and is a potential safe choice of topical anesthesia for surgeons if they choose to perform office procedures such as myringotomies or TT placement on children.\n                  <\/jats:p>","DOI":"10.1177\/01455613231212829","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T03:58:51Z","timestamp":1700798331000},"page":"408-412","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of Topical Phenol in Awake Young Children for Tympanostomy Tube Placement"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-8941","authenticated-orcid":false,"given":"Franklin L.","family":"Rimell","sequence":"first","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelagh","family":"Cofer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Truitt","sequence":"additional","affiliation":[{"name":"St. Cloud Ear, Nose &amp; Throat, St. Cloud, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Nimmons","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery, HealthPartners, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Raisen","sequence":"additional","affiliation":[{"name":"Prairie Sinus, Ear &amp; Allergy, Bismarck, ND, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215105005840"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500266628"},{"key":"e_1_3_2_4_2","unstructured":"Apdyne Phenol Applicator Kit Instructions for Use. Summit Medical. Accessed August 21 2023. https:\/\/summitmedicalusa.com\/wordpress\/wp-content\/uploads\/2022\/06\/IFU-26707-Rev-B-Apdyne-Phenol-Applicator-Kit-IFU-1.pdf"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01616.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12339"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.336"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000979"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209136812"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200109000-00027"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X20903125"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(91)90059-k"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28612"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.533"},{"key":"e_1_3_2_15_2","unstructured":"American Academy of Otolaryngology Head and Neck Surgery. Position statement: in-office placement of tubes in pediatric patients while awake. Published July 2019. Accessed August 21 2023. https:\/\/www.entnet.org\/resource\/in-office-placement-of-tubes-in-pediatric-patients-while-awake"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813487302"},{"key":"e_1_3_2_17_2","unstructured":"Phenol. DrugBank Online. Published June 13 2005. Updated August 03 2023. Accessed August 21 2023. https:\/\/go.drugbank.com\/drugs\/DB03255"},{"key":"e_1_3_2_18_2","unstructured":"National Center for Biotechnology Information. PubChem Compound Summary for CID 996 Phenol. Accessed August 21 2023. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Phenol"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196805000-00014"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200105000-00007"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320919656"},{"key":"e_1_3_2_22_2","unstructured":"Tunkel D Liu M. Office-based tympanostomy tube placement: a safe and efficient alternative. Healio News. Published April 20 2021. Accessed August 21 2023. https:\/\/www.healio.com\/news\/primary-care\/20210420\/officebased-tympanostomy-tube-placement-a-safe-and-efficient-alternative"},{"key":"e_1_3_2_23_2","unstructured":"FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women. US Food and Drug Administration. Published December 14 2016. Accessed August 21 2023. https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-fda-review-results-new-warnings-about-using-general-anesthetics-andsedationdrugsinyoungchildrenandpregnantwomen"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815608366"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.9.1040"},{"key":"e_1_3_2_26_2","unstructured":"Isaacson G. Overview of tympanostomy tube placement postoperative care and complications in children. UpToDate. Update October 31 2022. Accessed August 21 2023. https:\/\/www.uptodate.com\/contents\/overview-of-tympanostomy-tube-placement-postoperative-care-and-complications-in-children"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0952-8180(00)00180-x"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613231212829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613231212829","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613231212829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:29:56Z","timestamp":1783661396000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613231212829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,24]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/01455613231212829"],"URL":"https:\/\/doi.org\/10.1177\/01455613231212829","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,24]]}}}