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It is usually associated with immunosuppression and human immunodeficiency virus infection. PBL most commonly occurs in the oral cavity, lymph nodes, and in other extranodal sites. However, it rarely originates from bilateral sinuses. Herein, we report the case of a 59-year-old man diagnosed with primary PBL of the sinuses confirmed by endoscopic biopsy, imaging materials, histopathological examination, and immunohistochemistry. The patient underwent 4 cycles of chemotherapy and 22 rounds of radiation therapy for 8 months. Re-examination by sinus computed tomography revealed no obvious tumor tissue in the nasal cavity and sinuses, suggesting that treatment was effective. No local recurrence or distant metastasis was detected at 6-month follow-up after the end of treatment.<\/jats:p>","DOI":"10.1177\/01455613231213545","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:42:17Z","timestamp":1701330137000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Plasmablastic Lymphoma of The Paranasal Sinuses: A Rare Case Report"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-5911","authenticated-orcid":false,"given":"Zhijuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, General Hospital of Ningxia Medical University, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, General Hospital of Ningxia Medical University, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Ningxia Medical University, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaizhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, General Hospital of Ningxia Medical University, Yinchuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.59"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000234"},{"issue":"3","key":"e_1_3_2_4_2","first-page":"255","article-title":"Clinical and diagnosis analysis of malignant lymphoma in nasal cavity and paranasal sinus","volume":"29","author":"Zhu L","year":"2015","unstructured":"Zhu L, Fang P, Liu Y, Tong B. Clinical and diagnosis analysis of malignant lymphoma in nasal cavity and paranasal sinus. J Clin Otorhinolaryngol Head Neck Surg. 2015;29(3):255.","journal-title":"J Clin Otorhinolaryngol Head Neck Surg"},{"issue":"11","key":"e_1_3_2_5_2","article-title":"Nasal lymphoma presenting with contralateral proptosis and vision changes: a case report and literature review","volume":"12","author":"Kim H","year":"2020","unstructured":"Kim H, Kim L, Rotenberg B. Nasal lymphoma presenting with contralateral proptosis and vision changes: a case report and literature review. 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