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Although EBV-related disease presentations are similar, they can lead to oncogenic transformation with various clinical manifestations. A thorough workup with morphology, immunohistochemistry, and molecular studies is crucial for the diagnosis of EBV-positive polymorphic B-cell lymphoproliferative disorder, not otherwise specified (NOS), which is a new entity introduced by International Consensus Classification in 2022. We describe an interesting presentation of EBV-positive polymorphic B-cell lymphoproliferative disorder with laryngeal involvement to bring awareness to this entity and we would like to address the need for more accessible treatment options.<\/jats:p>","DOI":"10.1177\/01455613231226017","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T04:17:20Z","timestamp":1706069840000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Submucosal Epstein-Barr Virus Positive Polymorphic B-cell Lymphoproliferative Disorder of the Larynx: A Case Report"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-1633","authenticated-orcid":false,"given":"Sehreen","family":"Mumtaz","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estephania","family":"Candelo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murli","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-985X","authenticated-orcid":false,"given":"Liuyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-7123","authenticated-orcid":false,"given":"Alok A.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Bridges","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-3514","authenticated-orcid":false,"given":"Andres","family":"Cardona","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-6328","authenticated-orcid":false,"given":"Amy","family":"Rutt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina","family":"Berianu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald R.","family":"Butendieck","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mayo Clinic Florida, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12467"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.199"},{"issue":"1","key":"e_1_3_3_4_2","first-page":"223","article-title":"Differential diagnosis problems in a patient with dysphonia and chronic lymphocytic leukemia","volume":"31","author":"Gavrila GA","year":"2015","unstructured":"Gavrila GA, Mihaila RG, Manitiu I. 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