{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:27:54Z","timestamp":1786516074119,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Health Commission of Zhejiang Province, China","award":["#2021KY1186"],"award-info":[{"award-number":["#2021KY1186"]}]},{"name":"Technology Agency of Jinhua, China","award":["# 2022\u20133\u2013042"],"award-info":[{"award-number":["# 2022\u20133\u2013042"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study evaluated the surgical outcomes and complications of the endoscopic cartilage-perichondrium graft technique for treating intratympanic membrane cholesteatomas (ITMCs) with tympanic membrane (TM) perforation or an atrophic TM in adults.\n                    <jats:bold>Methods and Materials<\/jats:bold>\n                    : Clinical data on 11 adult ITMCs were analyzed retrospectively. The graft success and cholesteatoma recurrence were evaluated 12 months postoperatively.\n                    <jats:bold>Results:<\/jats:bold>\n                    Of the 11 patients with ITMC, TM perforation had occurred in 2 (18.2%) and an atrophic TM or TM scar healing occurred in 9 (81.8%). In endoscopy, keratin debris accumulation was seen at the superior edge of the perforation or atrophic TM. Computed tomography revealed that the cholesteatoma was confined to the TM. Intraoperatively, the epithelial invasion of the cholesteatoma was limited to the fibrous layer within the TM. Cartilage-perichondrium grafting was performed after removing the cholesteatoma. All the grafts were successful, and the perforations achieved complete closure by the final 12 month follow-up. Endoscopy revealed no recurrent cholesteatoma. Of the 9 patients with preoperative tinnitus, the tinnitus disappeared in 3 (33.3%), was relieved in 4 (44.4%), and was unchanged in 2 (22.2%). Of the 7 patients with an ear fullness preoperatively, the ear fullness disappeared in 6 (85.7%) and was relieved in 1 (14.3%). The mean air-bone gap improved from 28.6 dB preoperatively to 16.2 dB postoperatively.\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Endoscopic complete excision of an ITMC and cartilage-perichondrium graft without raising a tympanomeatal flap can lead to successful graft intake and improve the symptoms for the patients with ITMC combined with perforation or atrophic TM.\n                  <\/jats:p>","DOI":"10.1177\/01455613241227714","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T07:53:40Z","timestamp":1706342020000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cartilage-Perichondrium Myringoplasty for Managing Intratympanic Membrane Cholesteatomas With Chronic Otitis Media in Adults"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-9033","authenticated-orcid":false,"given":"Zhengcai","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Wenzhou Medical University Affiliated Yiwu Hospital, Yiwu, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery and Center of Sleep Medicine, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China"},{"name":"Shanghai Key Lab Sleep Disordered Breathing, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-441X","authenticated-orcid":false,"given":"Zhengnong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Lab Sleep Disordered Breathing, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otoeng.2022.03.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.01.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2023.2200437"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.05.005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2017.08.027"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0156-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556131008900808"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-023-03757-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2016.1807"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016485909129191"},{"issue":"6","key":"e_1_3_2_12_2","first-page":"357","article-title":"Intratympanic cholesteatoma","volume":"28","author":"Rappaport JM","year":"1999","unstructured":"Rappaport JM, Browning S, Davis NL. Intratympanic cholesteatoma. J Otolaryngol. 1999;28(6):357-361.","journal-title":"J Otolaryngol"},{"issue":"5","key":"e_1_3_2_13_2","first-page":"699","article-title":"A congenital tympanic membrane cholesteatoma (CTMC) in the adult: a case report","volume":"16","author":"Casale M","year":"2012","unstructured":"Casale M, De Franco A, Negri M, et al. A congenital tympanic membrane cholesteatoma (CTMC) in the adult: a case report. Eur Rev Med Pharmacol Sci. 2012;16(5):699-700.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109001217"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.5.501"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003141"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30523"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613241227714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613241227714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613241227714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:32:25Z","timestamp":1786512745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613241227714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/01455613241227714"],"URL":"https:\/\/doi.org\/10.1177\/01455613241227714","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,27]]}}}