{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:19:16Z","timestamp":1787807956690,"version":"build-2784847793"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ20H130001"],"award-info":[{"award-number":["LQ20H130001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23H130002"],"award-info":[{"award-number":["LY23H130002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To investigate the roles of proinflammatory cytokine IL-17 in the prognosis of laryngeal squamous cell carcinoma (LSCC).\n                    <jats:bold>Methods:<\/jats:bold>\n                    In all, 67 LSCC patients were enrolled to evaluate the expression of IL-17, IL-23, CD8, CD31, and vascular endothelial growth factor by immunohistochemical staining. Cumulative survival time was determined by the Kaplan-Meier approach, and prognostic variables for overall survival (OS) were identified by Cox proportional-hazards models.\n                    <jats:bold>Results:<\/jats:bold>\n                    The expression of IL-17 and IL-23 was remarkably higher in LSCC tissue than in adjacent normal (AN) tissue (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). The Kaplan-Meier analysis indicated that patients with cervical lymph node metastasis (CLNM), advanced tumor node metastasis (TNM) stage, poor-differentiated grade, high microvessel density (MVD) in LSCC tissues, and high IL-17 expression in AN tissues had poorer OS (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .05). Cox regression analysis revealed that CLNM (HR = 7.246; 95% CI: 2.598-20.208;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), high MVD in tumor tissues (HR = 4.233; 95% CI: 1.482-12.092;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .007), and low CD8 expression in AN tissues (HR = 3.996; 95% CI: 1.442-11.074;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .008) were significantly associated with poorer OS in LSCC, while IL-17 expression in AN tissue was not.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    High IL-17 expression in AN tissues could indicate poor prognosis and may be a prognostic marker for LSCC. Low CD8 expression in AN tissues may represent poor frontline antitumor immunity and be associated with poor prognosis.\n                  <\/jats:p>","DOI":"10.1177\/01455613241232500","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T04:14:00Z","timestamp":1707970440000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["IL-17 expression and prognosis of laryngeal squamous cell carcinoma"],"prefix":"10.1177","volume":"105","author":[{"given":"Yun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-3532","authenticated-orcid":false,"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.043"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4161\/2162402X.2014.984539"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12156"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018219"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.10.028"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215119000689"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1126857"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4161\/2162402X.2014.984547"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.24.1875"},{"issue":"14","key":"e_1_3_2_14_2","first-page":"779","article-title":"[Expression of IL-17 in laryngeal squamous cell carcinoma tissues and the clinical significance]","volume":"27","author":"Wang Y","year":"2013","unstructured":"Wang Y, Yang J, Xu H. [Expression of IL-17 in laryngeal squamous cell carcinoma tissues and the clinical significance]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013;27(14):779-783.","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2953191"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12465"},{"issue":"3","key":"e_1_3_2_17_2","first-page":"1876","article-title":"Expression of IL-17 with tumor budding as a prognostic marker in oral squamous cell carcinoma","volume":"11","author":"Zhang S","year":"2019","unstructured":"Zhang S, Wang X, Gupta A, Fang X, Wang L, Zhang C. Expression of IL-17 with tumor budding as a prognostic marker in oral squamous cell carcinoma. Am J Transl Res. 2019;11(3):1876-1883.","journal-title":"Am J Transl Res"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0422-y"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16053"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902574"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1758606"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-177360"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaa058"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613241232500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613241232500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613241232500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:36:45Z","timestamp":1787805405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613241232500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/01455613241232500"],"URL":"https:\/\/doi.org\/10.1177\/01455613241232500","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]}}}