{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:11:59Z","timestamp":1777561919303,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Health Commission of Zhejiang province, China","award":["#2021KY1186"],"award-info":[{"award-number":["#2021KY1186"]}]},{"name":"Technology Agency of Jinhua city","award":["#2022-3-042"],"award-info":[{"award-number":["#2022-3-042"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Objective: The objective of this study was to endoscopically evaluate the graft healing process and graft success rate following cartilage myringoplasty, without trimming of the perforation margin or external ear canal (EAC) packing. Material and Methods: Patients with chronic tympanic membrane (TM) perforation underwent endoscope cartilage underlay myringoplasty, without trimming perforation margin or EAC packing. The healing process of the cartilage graft and the graft success rate were evaluated at 6\u2009months postoperatively. Results: Fifty-eight ears were included in this study. At 1\u2009week postoperatively, clinical inosculation and neovascularization of the graft were observed in small- and medium-sized perforations, but not in large or subtotal perforations. At 2\u2009weeks postoperatively, graft clinical inosculation and neovascularization were completed in the small- and medium-sized perforations; however, neovascularization of the graft had only just begun in the large perforations. At 3\u2009weeks postoperatively, completion of the graft clinical inosculation was achieved in 57 of the 58 ears. At 4\u2009weeks postoperatively, complete neovascularization was achieved in all perforations. Of the 58 ears, postoperative infection resulted in residual perforation in 1 ear, and an insufficient graft resulted in residual perforation in a large perforation without infection. Overall, the graft success rate was 96.6% (56\/58). There was no correlation between the graft success rate and graft neovascularization score. Conclusions: The graft healing process experienced the dilation of the blood vessels of the remnant TM, graft clinical inosculation, and neovascularization following cartilage myringoplasty without trimming of the perforation margin and EAC packing; however, the graft success rate was not related to the endoscopic graft neovascularization scores.<\/jats:p>","DOI":"10.1177\/01455613241245210","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T01:52:05Z","timestamp":1712886725000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Graft Healing Process Following Cartilage Myringoplasty Without Trimming of the Perforation Margin"],"prefix":"10.1177","author":[{"given":"Meixia","family":"Wu","sequence":"first","affiliation":[{"name":"Central Sterile Supply Department, Yiwu Central Hospital, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-9033","authenticated-orcid":false,"given":"Zhengcai","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Wenzhou Medical University Affiliated Yiwu Hospital, Yiwu, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"bibr1-01455613241245210","volume-title":"StatPearls","author":"Danishyar A","year":"2023"},{"key":"bibr2-01455613241245210","volume-title":"StatPearls","author":"Brar S","year":"2023"},{"key":"bibr3-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820931491"},{"key":"bibr4-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14102"},{"key":"bibr5-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319840573"},{"key":"bibr6-01455613241245210","first-page":"1","volume":"287","author":"Reijnen CJ","year":"1971","journal-title":"Acta Otolaryngol Suppl"},{"issue":"4","key":"bibr7-01455613241245210","first-page":"295","volume":"32","author":"Boedts D.","year":"1978","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"bibr8-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215120000006"},{"key":"bibr9-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(00)80039-3"},{"key":"bibr10-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.05.005"},{"key":"bibr11-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100118845"},{"key":"bibr12-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12014"},{"key":"bibr13-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454257"},{"key":"bibr14-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500501"},{"key":"bibr15-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13863"},{"key":"bibr16-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30523"},{"key":"bibr17-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.381"},{"key":"bibr18-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106002660"},{"key":"bibr19-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107000928"},{"key":"bibr20-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0630"},{"key":"bibr21-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1155\/NP.1997.97"},{"key":"bibr22-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902580310"},{"key":"bibr23-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27239"},{"key":"bibr24-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002367"},{"key":"bibr25-01455613241245210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09804.x"}],"container-title":["Ear, Nose &amp; 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