{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:17:03Z","timestamp":1793863023974,"version":"4.6.1"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Objective: Evaluation of the effectiveness and posttreatment effects of intratympanic gentamicin and corticosteroids in treating patients with M\u00e9ni\u00e8re\u2019s disease (MD). Methods: Based on PubMed and Embase databases, randomized controlled trials using intratympanic injections of 4 drugs (gentamicin, methylprednisolone, dexamethasone, and placebo) for the treatment of MD were searched from 1995 to October 2023, and the literature was screened according to inclusion and exclusion criteria, and data were netted for meta-analysis using Stata 17. Results: A total of 13 studies were selected, involving 559 participants, with follow-up time ranging from 3 to 28 months. Meta-analysis showed that there was no statistically significant difference in pure-tone average between gentamicin and dexamethasone [standardized mean difference (SMD) = 0.09, 95% confidence interval (CI) (\u22120.42, 0.24), P &lt; .05]. Compared to placebo, intratympanic injection of gentamicin [risk ratio (RR) = 1.18, 95% CI (0.43, 1.93)], methylprednisolone [RR = 0.88, 95% CI (0.07, 1.70)], and dexamethasone [RR = 0.70, 95% CI (\u22120.01, 1.41)] all showed better efficacy in treating vertigo. For the treatment of tinnitus, the SUCRA ranking results showed that dexamethasone was the most effective, followed by methylprednisolone and gentamicin. Conclusion: Pharmacological intervention is more effective than placebo in treating MD. Although gentamicin treatment shows significant effects in treating vertigo, corticosteroid combination therapy is markedly superior to gentamicin in controlling hearing loss and vertigo symptoms.<\/jats:p>","DOI":"10.1177\/01455613241264421","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T06:53:01Z","timestamp":1719039181000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacological Interventions for Meni\u00e8re\u2019s Disease: A Systematic Review and Network Meta-Analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4979-8891","authenticated-orcid":false,"given":"Xian","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8039-9374","authenticated-orcid":false,"given":"Rui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"bibr1-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07374-y"},{"key":"bibr2-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103141"},{"key":"bibr3-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13350"},{"key":"bibr4-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10011-5"},{"key":"bibr5-01455613241264421","volume":"162","author":"Basura G J","year":"2020","journal-title":"Otolaryngol Head Neck Surg"},{"key":"bibr6-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31461-1"},{"key":"bibr7-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811429432"},{"key":"bibr8-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812472882"},{"key":"bibr9-01455613241264421","first-page":"171","volume":"28","author":"El-Beltagy YF","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"bibr10-01455613241264421","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/772"},{"key":"bibr11-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27392"},{"issue":"95","key":"bibr12-01455613241264421","first-page":"341","volume":"29","author":"Masoumi E","year":"2017","journal-title":"Iran J Otorhinolaryngol"},{"key":"bibr13-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.010"},{"key":"bibr14-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701762458"},{"key":"bibr15-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410016621"},{"key":"bibr16-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.119485"},{"issue":"5","key":"bibr17-01455613241264421","first-page":"193","volume":"16","author":"Akkuzu B","year":"2006","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"bibr18-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-02528-6"},{"issue":"7","key":"bibr19-01455613241264421","author":"Phillips JS","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"bibr20-01455613241264421","author":"Pullens B","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr21-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103086"},{"issue":"2","key":"bibr22-01455613241264421","volume":"2","author":"Webster KE","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr23-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3689-3"},{"key":"bibr24-01455613241264421","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.06.008"},{"key":"bibr25-01455613241264421","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1622"}],"container-title":["Ear, Nose &amp; 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