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Nasal examination, overall symptom scores, individual AR symptoms (nasal discharge, sneezing, nasal itching, and nasal obstruction), and quality of life (QoL) were assessed before and after 3 weeks of treatment with Rhinapi, the nasal spray made of hypertonic saline with Anatolian propolis added (Bee&amp;You, Istanbul, Turkey). Results: Rhinapi nasal drop use was associated with a substantial decrease ( P &lt; .05) in AR symptom ratings, including nasal discharge, sneezing, nasal itching, and nasal obstruction. QoL scores showed a significant improvement ( P &lt; .05), and the spray also alleviated swelling and improved concha color ( P &lt; .05). Conclusion: Rhinapi, Anatolian propolis\u2013added hypertonic saline nasal spray (Bee&amp;You, Istanbul, Turkey), when used for 3 weeks, reduced AR symptom scores and improved QoL. Both the concha color and the edema were also enhanced.<\/jats:p>","DOI":"10.1177\/01455613241290502","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:34:15Z","timestamp":1730680455000},"page":"168S-175S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A Prospective, Multicenter European Study on the Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms"],"prefix":"10.1177","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-1148","authenticated-orcid":false,"given":"Felicia","family":"Manole","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of ENT, University of Oradea, Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Hoermann","sequence":"additional","affiliation":[{"name":"Mannheim Medical Faculty, Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Mannheim, Ruprecht-Karls-Universit\u00e4t Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiderio","family":"Passali","sequence":"additional","affiliation":[{"name":"IFOS Former President, ORL Head and Neck Surgery, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Rombaux","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Maria Bellussi","sequence":"additional","affiliation":[{"name":"ENT Clinic, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rudenko","sequence":"additional","affiliation":[{"name":"Section of Allergy and Immunology, The London Allergy and Immunology Center, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Milkov","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, Medical University of Varna, Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Kopacheva-Barsova","sequence":"additional","affiliation":[{"name":"ENT University Hospital, University Campus \u201cSt. Mother Theresa\u201d Skopje, Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Prokopakis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Chabolle","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head, and Neck Surgery, Foch Hospital, Suresnes, 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