{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:23:11Z","timestamp":1781014991225,"version":"3.54.1"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is characterized by type 2 inflammation, and studies have shown that conventional therapy usually yields unsatisfactory results. While recent studies have indicated the potential effect of vitamin D on allergic and inflammatory diseases, including CRSwNP. Therefore, this study aimed to investigate the relationship between serum vitamin D levels and the severity of CRSwNP using endoscopic evaluations, imaging, patient-reported outcome measures, absolute eosinophilic count, and serum vitamin D levels and determine the prevalence of vitamin D deficiency in patients with CRSwNP. Methods: Serum vitamin D levels were measured in 104 patients with uncontrolled CRSwNP, who failed maximum medical management and were scheduled for functional endoscopic sinus surgery. Vitamin D levels were compared between patients using the Lund- Mackay (LM) score, Sinonasal Outcome Test-22 (SNOT-22), total nasal polyp scores, and absolute eosinophil counts. Results: The 104 included patients had an average age of 42.09 \u00b1 13.3 years, and 63.5% of them were male. Mean value of vitamin D was 57.9 \u00b1 31.2 nmol\/L. The average SNOT-22 score was 65.49 \u00b1 21.3. The mean LM score was 14.48 \u00b1 6.64. The total nasal polyp score was 4.3 \u00b1 2.08. Vitamin D levels were negatively correlated with LM score ( r = \u2212.210, P = .032) and polyp grade ( r = \u2212.264, P = .007), but did not correlate with other variables. Conclusions: Our study indicates that vitamin D deficiency or insufficiency is common in patients with CRSwNP. We found that low serum vitamin D levels were negatively correlated with the Lund-Mackay score and the total nasal polyp score, providing additional support for an association between low vitamin D levels and a greater severity of CRSwNP.<\/jats:p>","DOI":"10.1177\/01455613241302892","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:31:31Z","timestamp":1732681891000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Serum Vitamin D Level and Uncontrolled Chronic Rhinosinusitis With Nasal Polyposis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6451-1326","authenticated-orcid":false,"given":"Nasir A.","family":"Magboul","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head, and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi 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