{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:19:26Z","timestamp":1777562366801,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Primary thyroid lymphoma is rare. Hashimoto\u2019s disease is usually found as a risk factor. Among thyroid lymphoma, diffuse large B-cell lymphoma (DLBCL) is the most aggressive and frequent one. A 56-year-old man with a medical history of Hashimoto\u2019s disease presented with a neck mass and dysphonia. A computed tomography scan revealed a large thyroid mass. Fine-needle aspiration cytology (FNAC) was consistent with lymphoma, confirmed by a core needle as a DLBCL. The patient was transferred to the Department of Hematology and Oncology for chemotherapy with good results. Primary thyroid lymphoma accounts for less than 5% of all thyroid gland malignancies and less than 2% of extranodal lymphomas. It frequently affects women in the sixth or seventh decade. Hashimoto\u2019s disease is a major risk factor. DLBCL is the most common histological subtype with aggressive evolution. Radiology and FNAC are not usually very precise and a biopsy is needed. Treatment includes surgery, radiotherapy, chemotherapy, and targeted therapy.<\/jats:p>","DOI":"10.1177\/01455613241306034","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:49:27Z","timestamp":1733471367000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary Thyroid Diffuse Large B-Cell Lymphoma: A Case Report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0207-0016","authenticated-orcid":false,"given":"Makram","family":"Tbini","sequence":"first","affiliation":[{"name":"ENT Department, Charles Nicolle Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Bessioud","sequence":"additional","affiliation":[{"name":"ENT Department, Charles Nicolle Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumayma","family":"El Mabrouk","sequence":"additional","affiliation":[{"name":"ENT Department, Charles Nicolle Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rihab","family":"Laamouri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia"},{"name":"Endocrinology Department, Charles Nicolle Hospital, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriem","family":"Ksentini","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia"},{"name":"Pathology Department, Charles Nicolle Hospital, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlem","family":"Blel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia"},{"name":"Pathology Department, Charles Nicolle Hospital, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamia","family":"Ben Salah","sequence":"additional","affiliation":[{"name":"ENT Department, Charles Nicolle Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"bibr1-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.109126"},{"key":"bibr2-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1428"},{"key":"bibr3-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4436"},{"issue":"5","key":"bibr4-01455613241306034","first-page":"99","volume":"16","author":"Sun H","year":"2023","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr5-01455613241306034","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00542"},{"key":"bibr6-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-020-2204-2"},{"key":"bibr7-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01712-3"},{"key":"bibr8-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.983"},{"key":"bibr9-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2012.04.024"},{"key":"bibr10-01455613241306034","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.09.48"},{"key":"bibr11-01455613241306034","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1054584"},{"issue":"3","key":"bibr12-01455613241306034","volume":"16","author":"Ghafouri AM","year":"2024","journal-title":"Cureus"},{"key":"bibr13-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0095"},{"key":"bibr14-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0036"},{"key":"bibr15-01455613241306034","first-page":"3719320","volume":"2022","author":"Alnahas Z","year":"2022","journal-title":"Case Rep Endocrinol"},{"key":"bibr16-01455613241306034","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102443"},{"issue":"12","key":"bibr17-01455613241306034","first-page":"718","volume":"36","author":"Jones G","year":"2022","journal-title":"Oncology (Williston Park)"},{"issue":"1","key":"bibr18-01455613241306034","first-page":"75","volume":"32","author":"Dundar HZ","year":"2016","journal-title":"Ulus Cerrahi Derg"},{"key":"bibr19-01455613241306034","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1064050"},{"key":"bibr20-01455613241306034","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.965448"}],"container-title":["Ear, Nose &amp; 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