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Complete excision of the right submandibular gland and the scalp swelling was performed. The case was diagnosed as metastasizing pleomorphic adenoma. The exact cause of the malignant manifestation of this histologically benign entity is unclear. The time of appearance of a metastatic deposit is highly variable and is usually preceded by a local recurrence. Further research on the malignant behavior of this entity is warranted.<\/jats:p>","DOI":"10.1177\/01455613251314609","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T22:02:33Z","timestamp":1738101753000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleomorphic Adenoma of the Submandibular Gland with Skull Metastasis: A Case Report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6966-4572","authenticated-orcid":false,"given":"Prankur","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Christian Medical College, Vellore, TN, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit Jiwan","family":"Tirkey","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Christian Medical College, Vellore, TN, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Vandana","family":"Jyothi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Christian Medical College, Vellore, TN, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vartika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Christian Medical College, Vellore, TN, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond Jonathan","family":"Gandham","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Christian Medical College, Vellore, TN, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"bibr1-01455613251314609","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0815-0"},{"key":"bibr2-01455613251314609","first-page":"165","volume-title":"Surgical Pathology of the Salivary Glands","volume":"1991","author":"Ellis G"},{"key":"bibr3-01455613251314609","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000153450.87288.2a"},{"key":"bibr4-01455613251314609","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0347(199710)19:7<629::aid-hed11>3.0.co;2-y"},{"key":"bibr5-01455613251314609","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.04.084"},{"key":"bibr6-01455613251314609","unstructured":"BB9.pdf. 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