{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:51:43Z","timestamp":1783122703315,"version":"3.54.6"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Background:Respiratory epithelial adenomatoid hamartoma (REAH) is a benign pseudo-glandular proliferation of the nasal cavity with poorly-understood etiopathogenesis. This study aimed to examine the frequency of comorbidities in patients with REAH and to determine whether comorbidity affects the clinical characteristics of REAH. Methods: A retrospective cohort study included patients with REAH treated at 2 university hospitals over 15 years. Clinical parameters included the side of the nasal cavity, localization and size of the lesion, duration of symptoms, follow-up period, and associated chronic inflammation. Results: Twenty previously-unoperated patients with REAH were included. We found an association of REAH with chronic sinonasal disorders in 70% of cases: in 30% with perennial allergic rhinitis (PAR), in 25% with chronic rhinosinusitis with nasal polyps (CRSwNP), and in 15% of cases with aspirin-exacerbated respiratory disease (AERD). In 87.5% of cases of bilateral REAH, the lesion was associated with NPs, in 80% of patients with CRSwNP as a comorbidity, and in 100% of patients where it was AERD. Symptoms were longer in REAH patients with associated sinonasal inflammation ( P &lt; .038). We found a far-greater average volume of REAH in patients with AERD than in cases with PAR, and CRSwNP ( P &lt; .001; P &lt; .001, respectively) and a positive correlation between the duration of symptoms and the lesion volume ( R = .700; P = .001). The follow-up period was longer in patients with comorbidities ( P &lt; .028), and recurrences of REAH were noted only in 2 patients with AERD as a comorbidity. Conclusion: A high degree of association between REAH and chronic sinonasal inflammation was found. Also, the results suggest that inflammation in AERD is the strongest provoking factor for the growth of REAH. A direct correlation was observed between the duration of nasal symptoms and the lesion size.<\/jats:p>","DOI":"10.1177\/01455613251321980","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T23:38:33Z","timestamp":1740353913000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic Sinonasal Inflammation as a Comorbidity of Respiratory Epithelial Adenomatoid Hamartoma: A 15-Year Retrospective Observational Study"],"prefix":"10.1177","author":[{"given":"Biserka","family":"Vukomanovi\u0107 \u0110ur\u0111evi\u0107","sequence":"first","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Jovan\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Otorhinolaryngology and Head and Neck Surgery, University Clinical Center of Vojvodina, Novi Sad, Serbia"},{"name":"University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia"},{"name":"University Clinical Center of Vojvodina, Center for Histology and Pathology, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Labus","sequence":"additional","affiliation":[{"name":"Institute of Aviation Medicine, Military Medical Academy, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Bo\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Otorhinolaryngology and Head and Neck Surgery, University Clinical Center of Vojvodina, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7870-3103","authenticated-orcid":false,"given":"Tamara","family":"Zelenovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Otorhinolaryngology and Head and Neck Surgery, University Clinical Center of Vojvodina, Novi Sad, Serbia"},{"name":"University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Baleti\u0107","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-7272","authenticated-orcid":false,"given":"Aleksandar","family":"Peri\u0107","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine of the Military Medical 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