{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:20:32Z","timestamp":1777562432239,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Yunnan Digestive Endoscopy Clinical Medical Center Foundation for Health Commission of Yunnan Province","award":["2022LCZXKF-XH10"],"award-info":[{"award-number":["2022LCZXKF-XH10"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare, low-grade malignant neoplasm originating in the nasal cavity and paranasal sinuses. This report provides a detailed account of the clinical and pathological characteristics of a single case of SNRCLA, highlights its differential diagnosis, and includes a review of relevant literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description:<\/jats:title>\n                    <jats:p>A 13-year-old male presented with a mass in the right nasal cavity. Histopathological analysis demonstrated tumor morphology analogous to clear cell renal cell carcinoma, characterized by abundant clear cytoplasm, acinar formations, and a prominent capillary-rich stroma. Immunohistochemical analysis revealed positive staining for cytokeratin pan, cytokeratin 7, vimentin, carbonic anhydrase IX, and SRY-box 10, with partial positivity for S-100. Markers such as paired box 8, atriopeptidase, renal cell carcinoma marker, melanosome, thyroglobulin, and thyroid transcription factor-1were negative. Fluorescence in situ hybridization analysis identified the presence of an EWSR1 gene rearrangement. The patient underwent surgical resection followed by adjuvant radiotherapy. Follow-up evaluations conducted as of November 2024 revealed no evidence of tumor recurrence, and the patient remained in good general health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SNRCLA is a rare neoplasm characterized by its low incidence rate and the necessity for exclusion-based diagnosis, requiring differentiation from other clear cell tumors. Immunohistochemistry plays a key role in establishing the diagnosis and distinguishing SNRCLA from histologically-similar entities. This case represents the first documentation of EWSR1 gene rearrangement in SNRCLA, thereby contributing novel insights into its molecular profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613251323776","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T10:09:31Z","timestamp":1740650971000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report of a Primary Sinonasal Renal Cell-Like Adenocarcinoma With\n                    <i>EWSR1<\/i>\n                    Gene Rearrangement in a 13-Year-Old Male"],"prefix":"10.1177","author":[{"given":"Ming","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Pathology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6283-3524","authenticated-orcid":false,"given":"Xuan-Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"bibr1-01455613251323776","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0794-1"},{"key":"bibr2-01455613251323776","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.05.014"},{"key":"bibr3-01455613251323776","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.4.441"},{"key":"bibr4-01455613251323776","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007-8096.2021.02.001"},{"key":"bibr5-01455613251323776","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112151-20200206-00070"},{"key":"bibr6-01455613251323776","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14285"},{"key":"bibr7-01455613251323776","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38321"},{"key":"bibr8-01455613251323776","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105705"},{"key":"bibr9-01455613251323776","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25338"},{"key":"bibr10-01455613251323776","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0854-3"},{"key":"bibr11-01455613251323776","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0774-x"},{"issue":"11","key":"bibr12-01455613251323776","first-page":"1330","volume":"31","author":"Sun YX","year":"2024","journal-title":"Chin J Bases Clin Gen Surg"},{"key":"bibr13-01455613251323776","doi-asserted-by":"publisher","DOI":"10.19538\/j.cjps.issn1005-2208.2022.06.05"}],"container-title":["Ear, Nose &amp; 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