{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:31:59Z","timestamp":1777563119944,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the New Technologies of Endoscopic Surgery in Skull Base Tumor: CAMS Innovation Fund for Medical Sciences","award":["2019-I2M-5-003"],"award-info":[{"award-number":["2019-I2M-5-003"]}]},{"DOI":"10.13039\/501100001809","name":"the China National Natural Science Foundation","doi-asserted-by":"crossref","award":["82301278"],"award-info":[{"award-number":["82301278"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aimed to explore survival outcomes of and prognostic factors in nasopharyngeal mucoepidermoid carcinoma (NPMEC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>We reviewed a total of 57 patients diagnosed with NPMEC, including 19 patients in our center and 38 patients with detailed individual survival data in the literature. The Kaplan-Meier method and the log-rank test were used to assess overall survival (OS) and progression-free survival (PFS). Furthermore, the multivariate survival analysis was evaluated using the Cox regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The average age of the patients was 45.8 years (range 13-71 years), with a male-to-female ratio of 0.84. During the mean follow-up time of 49 months (range, 3-149 months), the OS rates at 1, 3 and 5 years were 96.1%, 78.7%, and 62.8%, respectively, and the PFS rates at 1, 3 and 5 years were 91.4%, 71.6%, and 51.3%, respectively. The log-rank test showed that lymphatic metastasis affected OS and PFS, while stage T affected PFS. Multivariate regression analysis showed that lymphatic metastasis was associated with worse OS and PFS, that stage T was associated with unfavorable PFS, and that combined therapy improved PFS independently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with NPMEC have favorable 5 year OS and PFS. Lymphatic metastasis was the independent factor for OS, while lymphatic metastasis, stage T, and treatment modality were the independent factors for PFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613251336876","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T02:39:02Z","timestamp":1747795142000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Analysis and Prognostic Factors for Nasopharyngeal Mucoepidermoid Carcinoma"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-0085","authenticated-orcid":false,"given":"Yuting","family":"Lai","sequence":"first","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaole","family":"Song","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"},{"name":"Mucosal Melanoma Diagnosis and Treatment Center, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huankang","family":"Zhang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanpeng","family":"Li","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Yang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xicai","family":"Sun","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"},{"name":"Nasal Adenoid Cystic Carcinoma Subspecialty, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehui","family":"Wang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmeng","family":"Yu","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, Fudan University, Shanghai, China"},{"name":"Research Units of New Technologies of Endoscopic Surgery in Skull Base Tumor, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"63","article-title":"Well differentiated nasopharyngeal adenocarcinoma. Pathologic analysis of 34 cases","volume":"96","author":"Zong YS","year":"1983","unstructured":"Zong YS, Zhang RF, Chen ZH. Well differentiated nasopharyngeal adenocarcinoma. Pathologic analysis of 34 cases. Chin Med J (Engl). 1983;96:63-68.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0787-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002618"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.06.001"},{"issue":"1","key":"e_1_3_2_6_2","first-page":"164","article-title":"Nasopharyngeal mucoepidermoid carcinoma \u2013 a common entity at an uncommon location","volume":"8","author":"Hemalatha AL","year":"2014","unstructured":"Hemalatha AL, Sharath Kumar HK, Geetanjali S, Giripunja M, Shashikumar SD. Nasopharyngeal mucoepidermoid carcinoma \u2013 a common entity at an uncommon location. 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