{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:33:46Z","timestamp":1777563226038,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Adenoidectomy, routinely performed for pediatric obstructive symptoms, typically reveals benign lymphoid hyperplasia. We report the first documented case of a primary clear cell microcystic adenoma within adenoid tissue in a 12-year-old male undergoing adenotonsillectomy for chronic snoring, recurrent tonsillitis, and mouth breathing. Intraoperative examination identified an unusual homogenous grayish-white adenoid mass. Histopathological analysis demonstrated benign epithelial hyperplasia with focal clusters of clear cells arranged in microcystic patterns, morphologically aligning with a low-grade microcystic adenoma\u2014a lesion classically linked to von Hippel-Lindau (VHL) syndrome. This case emphasizes the critical role of histopathological scrutiny in routine surgical specimens, as incidental findings may reveal rare neoplasms with significant syndromic implications. While the lesion exhibited benign features, its histological resemblance to VHL-driven neoplasms necessitates vigilant long-term surveillance. This report advocates for multidisciplinary collaboration in managing such cases and highlights the importance of genetic assessment to guide familial screening. Further documentation of similar cases is required to establish this entity\u2019s clinical and molecular profile, refining diagnostic approaches for nasopharyngeal clear cell lesions.<\/jats:p>","DOI":"10.1177\/01455613251352716","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T03:28:54Z","timestamp":1750735734000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nasopharyngeal Microcystic Clear Cell Adenoma in a Child: A Rare Case Report"],"prefix":"10.1177","author":[{"given":"Ruba","family":"Mshref","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"},{"name":"Otolaryngology\u2014Head and Neck Surgery Department, Al Hilal Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-8547","authenticated-orcid":false,"given":"Ahmad","family":"Alkheder","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"},{"name":"Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Naief","family":"Sharaf Aldeen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"},{"name":"Otolaryngology\u2014Head and Neck Surgery Department, Al Hilal Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Mshref","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Pathology, Faculty of Dentistry, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham","family":"Eid","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raouf Salem","family":"seif eddin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"},{"name":"Otolaryngology\u2014Head and Neck Surgery Department, Al Hilal Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2021.04.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22373"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-024-10176-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333988"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9236780"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318223b7a7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64799-2"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613251352716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613251352716","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613251352716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:38:48Z","timestamp":1777401528000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613251352716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":7,"alternative-id":["10.1177\/01455613251352716"],"URL":"https:\/\/doi.org\/10.1177\/01455613251352716","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]},"article-number":"01455613251352716"}}