{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:33:50Z","timestamp":1777563230390,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm rarely encountered in the pediatric larynx, with the subglottis representing an atypical subsite. This report details a diagnostically instructive case of a 10-year-old girl presenting with 18 months of progressive dyspnea and exertional stridor, notably without hoarseness. Fibroendoscopic laryngoscopy identified a well-circumscribed right subglottic mass, confirmed on computed tomography scan to cause partial airway narrowing. The lesion\u2019s firm intraoperative consistency contrasted with common benign mimics. Histopathology revealed spindle cell proliferation with mixed inflammation (histiocytes, giant cells), while immunohistochemistry demonstrated focal anaplastic lymphoma kinase (ALK) and smooth muscle actin (SMA) positivity, CD68+ histiocytes, and CD1A negativity\u2014collectively confirming IMT and excluding Langerhans cell histiocytosis. Complete endoscopic excision was achieved. This case underscores critical learning points: (1) IMT must be considered in children with progressive stridor\/dyspnea, even lacking hoarseness, particularly with subglottic localization, and firm consistency; (2) Subglottic IMTs primarily manifest airway obstruction rather than voice changes typical of glottic lesions; (3) Focal ALK expression, present here, supports clonality but does not preclude a favorable outcome with complete resection; and (4) Immunohistochemistry (ALK\/SMA\/CD68\/CD1A) is indispensable for accurate diagnosis and avoiding misdirected therapy. Despite excellent early postoperative results consistent with the generally favorable prognosis of pediatric IMT, vigilance for recurrence\u2014highest within the first 2 years\u2014remains essential. This report reinforces complete conservative resection as the cornerstone of management for localized disease, reserving adjuvant therapies for complex or recurrent scenarios. Multidisciplinary collaboration optimizes outcomes while preserving laryngeal integrity in children.<\/jats:p>","DOI":"10.1177\/01455613251353637","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:57:39Z","timestamp":1750852659000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Subglottic Inflammatory Myofibroblastic Tumor in a Child: A Rare Case Report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-8547","authenticated-orcid":false,"given":"Ahmad","family":"Alkheder","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria"},{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-5122","authenticated-orcid":false,"given":"Yasser","family":"Al-Ghabra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria"},{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7260-5613","authenticated-orcid":false,"given":"Adel","family":"Azar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria"},{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Dmirieh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria"},{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adham Bader Aldeen","family":"Mohsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmajeed","family":"Yousfan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria"},{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"109","volume-title":"WHO Classification of Tumours. Soft Tissue and Bone Tumours","author":"Yamamoto H","unstructured":"Yamamoto H. Inflammatory myofibroblastic tumour. In: The WHO Editorial Board, ed. WHO Classification of Tumours. Soft Tissue and Bone Tumours. 5th ed. IARC Press; 2020:109-111.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.32213"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.07.050"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPCG8D6JAQBVLG"},{"issue":"2","key":"e_1_3_2_6_2","first-page":"187","article-title":"Laryngeal myofibroblastic tumor: case series and literature review","volume":"5","author":"Alhumaid H","year":"2011","unstructured":"Alhumaid H, Bukhari M, Rikabi A, et al. Laryngeal myofibroblastic tumor: case series and literature review. Int J Health Sci (Qassim). 2011;5(2):187-195.","journal-title":"Int J Health Sci (Qassim)"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-016-0967-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.049387"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(88)80264-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020-0352"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613251353637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613251353637","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613251353637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:38:49Z","timestamp":1777401529000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613251353637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":9,"alternative-id":["10.1177\/01455613251353637"],"URL":"https:\/\/doi.org\/10.1177\/01455613251353637","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"article-number":"01455613251353637"}}