{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:34:09Z","timestamp":1777563249639,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"\n Background:<\/jats:title>\n Sinonasal adenoid cystic carcinoma (ACC) is a rare, aggressive malignancy that commonly involves the nasal cavity and paranasal sinuses, with a propensity for perineural invasion and distant spread. Diffusion-weighted imaging (DWI) is a useful tool for evaluating tumor characteristics and monitoring treatment response. This case series aims to review the pre- and post-treatment diffusion characteristics of sinonasal ACC, focusing on the apparent diffusion coefficient (ADC) values.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A series of 8 cases of sinonasal ACC that underwent pre- and post-treatment magnetic resonance imaging with DWI were retrospectively analyzed. Circular regions of interest were drawn on representative ADC images of the lesions.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Pre-treatment mean ADC values ranged from 651 to 1156\u2009\u00d7\u200910\n \u22126<\/jats:sup>\n \u2009mm\n 2<\/jats:sup>\n \/second, while the post-treatment average ADC values ranged from 1351 to 1879\u2009\u00d7\u200910\n \u22126<\/jats:sup>\n \u2009mm\n 2<\/jats:sup>\n \/second. Post-treatment changes in ADC values were observed in all cases, demonstrating an increase in ADC, indicative of positive treatment response.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This case series suggests that DWI could serve as a non-invasive imaging tool for evaluating post-treatment response of sinonasal ADC. Post-treatment changes in ADC potentially correlate with treatment response and disease progression. Hence, DWI could play a supplemental role in monitoring therapy, highlighting its potential in guiding clinical management decisions for patients with sinonasal ACC.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/01455613251356364","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T10:30:17Z","timestamp":1754994617000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre- and Post-Treatment Diffusion-Weighted Imaging Characteristics of Sinonasal Adenoid Cystic Carcinoma"],"prefix":"10.1177","author":[{"given":"Mahlet Worku","family":"Molla","sequence":"first","affiliation":[{"name":"Federal Prison Commission General Hospital, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadieska","family":"Caballero","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Chicago Medicine, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-4364","authenticated-orcid":false,"given":"Daniel Thomas","family":"Ginat","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Chicago Medicine, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"826436","article-title":"An unusual presentation of adenoid cystic carcinoma","volume":"2015","author":"Gill KS","year":"2015","unstructured":"Gill KS, Frattali MA. 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Heliyon. 2023;9(11):e21901.","journal-title":"Heliyon"},{"issue":"8","key":"e_1_3_2_5_2","first-page":"748","article-title":"Adenoid cystic carcinoma of the head and neck: an update","volume":"51","author":"Coca-Pelaz A","year":"2015","unstructured":"Coca-Pelaz A, Rodrigo JP, Bradley PJ, et al. Adenoid cystic carcinoma of the head and neck: an update. Oral Oncol. 2015;51(8):748-757.","journal-title":"Oral Oncol"},{"issue":"5","key":"e_1_3_2_6_2","first-page":"392","article-title":"Advances in imaging in the work-up of head and neck cancer patients","volume":"45","author":"de Bree R","year":"2009","unstructured":"de Bree R, Castelijns JA, Hoekstra OS, Leemans CR. Advances in imaging in the work-up of head and neck cancer patients. Oral Oncol. 2009;45(5):392-397.","journal-title":"Oral Oncol"},{"key":"e_1_3_2_7_2","first-page":"29","article-title":"Staging and follow-up of high-grade malignant salivary gland tumors: the role of traditional versus functional imaging approaches \u2013 a review","volume":"56","author":"Freling N","year":"2016","unstructured":"Freling N, Crippa F, Maroldi R. Staging and follow-up of high-grade malignant salivary gland tumors: the role of traditional versus functional imaging approaches \u2013 a review. Oral Oncol. 2016;56:29-37.","journal-title":"Oral Oncol"},{"issue":"5","key":"e_1_3_2_8_2","first-page":"283","article-title":"Diagnostic value of diffusion-weighted magnetic resonance imaging for local and skull base recurrence of nasopharyngeal carcinoma after radiotherapy","volume":"45","author":"Wang C","year":"2018","unstructured":"Wang C, Liu L, Lai S, et al. Diagnostic value of diffusion-weighted magnetic resonance imaging for local and skull base recurrence of nasopharyngeal carcinoma after radiotherapy. J Neuroradiol. 2018;45(5):283-290.","journal-title":"J Neuroradiol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4867"},{"issue":"8","key":"e_1_3_2_10_2","first-page":"744","article-title":"The molecular biology of adenoid cystic carcinoma","volume":"48","author":"Liu J","year":"2012","unstructured":"Liu J, Shao C, Tan ML, et al. The molecular biology of adenoid cystic carcinoma. Oral Oncol. 2012;48(8):744-749.","journal-title":"Oral Oncol"},{"issue":"3","key":"e_1_3_2_11_2","first-page":"328","article-title":"Adenoid cystic carcinoma of the oral cavity: radiology-pathology correlation","volume":"11","author":"Uraizee I","year":"2017","unstructured":"Uraizee I, Cipriani NA, Ginat DT. Adenoid cystic carcinoma of the oral cavity: radiology-pathology correlation. Head Neck Pathol. 2017;11(3):328-334.","journal-title":"Head Neck Pathol"},{"issue":"3","key":"e_1_3_2_12_2","first-page":"379","article-title":"Diffusion-weighted imaging in head and neck cancers","volume":"25","author":"Chawla S","year":"2015","unstructured":"Chawla S, Kim S, Wang S, Poptani H. Diffusion-weighted imaging in head and neck cancers. J Neuroimaging. 2015;25(3):379-387.","journal-title":"J Neuroimaging"},{"key":"e_1_3_2_13_2","first-page":"23","article-title":"Application of diffusion-weighted MR imaging with ADC measurement for distinguishing between the histopathological types of sinonasal neoplasms","volume":"58","author":"Gencturk M","year":"2019","unstructured":"Gencturk M, Ozturk K, Caicedo-Granados E, Li F, Cayci Z. Application of diffusion-weighted MR imaging with ADC measurement for distinguishing between the histopathological types of sinonasal neoplasms. 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