{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:35:19Z","timestamp":1777563319290,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Carotid body tumors (CBTs) are rare neurogenic tumors that may indirectly affect cardiac autonomic regulation. This study aims to investigate the relationship between tumor size and electrocardiographic (ECG) findings, particularly the corrected QT (QTc) interval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study included 21 patients with histologically or radiologically confirmed CBTs treated at a tertiary center between 2021 and 2025. Patients with comorbidities or medications affecting cardiac conduction were excluded. Tumor sizes were measured via contrast-enhanced computed tomography or magnetic resonance imaging. Preoperative ECGs were analyzed for heart rate, P wave, PR, QRS, T wave, and QTc intervals. The correlation between tumor size and ECG parameters was assessed using Spearman\u2019s rank correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A statistically significant and strong positive correlation was observed between tumor size and QTc interval (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.940,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). No other ECG parameter showed a significant association with tumor size. Tumor size explained 88.36% of the variance in QTc duration (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.8836).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study demonstrates a strong correlation between CBT size and QTc prolongation, suggesting vagal overactivity as a possible mechanism. QTc may serve as a noninvasive marker of subclinical autonomic dysregulation in CBT patients. Larger prospective studies are warranted to validate this association and explore its clinical significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613251377560","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:44:12Z","timestamp":1758361452000},"page":"776-780","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Relationship Between Tumor Size and Electrocardiographic Findings in Carotid Body Paragangliomas: A Retrospective Observational Study"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2851-0849","authenticated-orcid":false,"given":"Ahmet","family":"Baki","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2184-9850","authenticated-orcid":false,"given":"Berkay","family":"G\u00fczel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0464-5190","authenticated-orcid":false,"given":"O\u011fuzhan","family":"Cumal\u0131","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-8224","authenticated-orcid":false,"given":"\u015eahin","family":"\u00d6\u011freden","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0298-8589","authenticated-orcid":false,"given":"\u0130skender","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zg\u00fcr","family":"Yi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-6811","authenticated-orcid":false,"given":"Emrah","family":"Bozbeyo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6512-8577","authenticated-orcid":false,"given":"Ece","family":"Eskici","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.706"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2019"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199808)20:5<374::AID-HED3>3.0.CO;2-V"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.10.019"},{"issue":"2","key":"e_1_3_2_6_2","first-page":"86","article-title":"Diagnosis and surgical treatment of carotid body tumors","volume":"16","author":"Matarac\u0131 I","year":"2008","unstructured":"Matarac\u0131 I, B\u00fclent Rabu\u015f M, K\u0131rali K, et al. Diagnosis and surgical treatment of carotid body tumors. Turk J Thorac Cardiovasc Surg. 2008;16(2):86-90.","journal-title":"Turk J Thorac Cardiovasc Surg"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.05.076"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27147"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574418761722"},{"issue":"8","key":"e_1_3_2_10_2","first-page":"1463","article-title":"Carotid body hypersensitivity in intermittent hypoxia and cardiovascular disease","volume":"601","author":"Prabhakar NR","year":"2023","unstructured":"Prabhakar NR, Nanduri R, Peng Y-J, Kumar GK, Wang N, Semenza GL. Carotid body hypersensitivity in intermittent hypoxia and cardiovascular disease. 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