{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:35:39Z","timestamp":1777563339108,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nanjing medical science and technology development fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To analyze the pathophysiological changes in the inner ear in different hearing loss patterns by observing the magnetic resonance imaging (MRI) characteristics of patients with sudden sensorineural hearing loss (SSNHL) and to evaluate the diagnostic value of T1WI\/T2WI combined with delayed enhanced intravenous 3D-FLAIR MR technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this single-center retrospective study, we performed T1WI, T2WI, and delayed enhanced intravenous 3D-FLAIR MR in 215 patients with SSNHL. Two radiologists independently assessed the MR image. Patients diagnosed with SSNHL were classified into 4 groups according to the audiogram of hearing loss: low-frequency group, flat audiogram group, high-frequency group, and profound deafness group. The MRI findings were classified into inner ear hemorrhage, endolymphatic hydrops (EH), labyrinthitis, or hemorrhagic labyrinthitis, and statistical analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 215 cases (99 males\/116 females; aged 46.69\u2009\u00b1\u200915.06) were included. Patients with the T1WI and T2WI scan accounted for 158 cases, patients with delayed enhancement accounted for 176 cases, and those with T1WI, T2WI, and delayed enhancements accounted for 118 cases. The abnormal MRI results\u2019 rates in the low-frequency group, flat audiogram group, high-frequency group, and profound deafness group were 25.9%, 33.78%, 24.32%, and 97.82%, respectively. The profound deafness group exhibited significantly higher incidences of inner ear hemorrhage (28.26%), labyrinthitis (45.65%), and hemorrhagic labyrinthitis (23.91%) compared to the low-frequency group (0.00%, 6.90%, 0.00%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), flat audiogram group (2.70%, 13.51%, 1.35%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and high-frequency group (5.41%, 13.51%, 0.00%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). EH were more prevalent in the low-frequency group (18.97%) and flat audiogram group (16.22%) than in the profound deafness group (0.00%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MRI technology can show the pathological change process of the inner ear partially, patients with SSNHL may present with labyrinthitis, hemorrhagic labyrinthitis, EH, hemorrhage of the inner ear, which may be interrelated or mutually transformed, and may be related to the severity and prognosis of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613251383663","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T10:39:14Z","timestamp":1761734354000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application Analysis of T1WI and T2WI Combined with Delayed Enhanced Magnetic Resonance Technology in Sudden Sensorineural Hearing Loss"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8742-1697","authenticated-orcid":false,"given":"Qingyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology Department, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, JiangSu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-7806","authenticated-orcid":false,"given":"Yating","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, JiangSu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-6607","authenticated-orcid":false,"given":"Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, JiangSu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2018.04.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13113303"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-014-0290-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02155-7"},{"issue":"6","key":"e_1_3_2_6_2","first-page":"443","article-title":"Otorhinolaryngology head and neck surgery branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of sudden deafness","volume":"50","author":"Editorial Committee of Chinese Journal of Otorhinolaryngology Head and Neck Surgery","year":"2015","unstructured":"Editorial Committee of Chinese Journal of Otorhinolaryngology Head and Neck Surgery. Otorhinolaryngology head and neck surgery branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of sudden deafness. Chinese J Otorhinolaryngol Head Neck Surg. 2015;50(6):443-447.","journal-title":"Chinese J Otorhinolaryngol Head Neck Surg"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6410"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13432"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903143986"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0588-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2821"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4439"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3856"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.03.032"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2010.534114"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00330-5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000758"},{"key":"e_1_3_2_18_2","volume-title":"Schuknecht\u2019s Pathology of the Ear","author":"Merchant SN","year":"2010","unstructured":"Merchant SN, Nadol JB, eds. Schuknecht\u2019s Pathology of the Ear. 3rd ed. People\u2019s Medical Publishing House, USA, 2010.","edition":"3"},{"issue":"2","key":"e_1_3_2_19_2","first-page":"116","article-title":"Hematocele in labyrinth causing sensorineural hearing loss in guinea pigs","volume":"14","author":"Changqiang T","year":"2006","unstructured":"Changqiang T, Fan G. Hematocele in labyrinth causing sensorineural hearing loss in guinea pigs. J Audiol Speech Pathol 2006;14(2): 116-120.","journal-title":"J Audiol Speech Pathol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200201000-00002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318172ef85"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613251383663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613251383663","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613251383663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:39:10Z","timestamp":1777401550000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613251383663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":20,"alternative-id":["10.1177\/01455613251383663"],"URL":"https:\/\/doi.org\/10.1177\/01455613251383663","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"article-number":"01455613251383663"}}