{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:45:59Z","timestamp":1782618359377,"version":"3.54.5"},"reference-count":48,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Children with genetic syndromes, especially Down syndrome (DS), are considered high-risk candidates for adenotonsillectomy (AT) due to anatomical abnormalities and comorbidities. This study aimed to evaluate the safety of AT in patients with DS and other genetic syndromes (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study included 62 syndromic patients (46 DS, 16 OS) under 18\u2009years of age who underwent tonsillectomy\u2009\u00b1\u2009adenoidectomy\u2009\u00b1\u2009ventilation tube (VT) insertion between 2010 and 2025. Demographics, comorbidities, surgical details, complications, and hospital stays were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Indications included sleep-disordered breathing (51\/62, 82.3%) and recurrent tonsillitis (16\/62, 25.8%). Procedures performed were AT (51\/62, 82.3%) or tonsillectomy alone (11\/62, 17.7%)\u2009\u00b1\u2009VT insertion (16\/62, 25.8%). Median hospital stay was 1\u2009day (IQR: 1-1), with 93.5% (58\/62) discharged after 1\u2009day. Two-day stays occurred in 18.75% of OS patients (3\/16) and 2.2% of DS patients (1\/46). Planned intensive care unit admission was required in 2 OS patients (3.2%). No emergency admissions or perioperative mortality occurred. Overall complication rate was 8.1% (5\/62)\u20148.7% in DS and 6.3% in OS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20091.00)\u2014including bleeding requiring reoperation (1\/62, 1.6%), respiratory event (1\/62, 1.6%), and insufficient oral intake (3\/62, 4.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AT appears to be safe in children with genetic syndromes, with low rates of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613251392448","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:01:03Z","timestamp":1761969663000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety of Adenotonsillectomy in Children with Genetic Syndromes"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-8599","authenticated-orcid":false,"given":"Comert","family":"Sen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-7270","authenticated-orcid":false,"given":"\u00d6mer","family":"Orak","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5044-6639","authenticated-orcid":false,"given":"T\u00fclay","family":"G\u00fcnsay","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1982-0386","authenticated-orcid":false,"given":"Said","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2563-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.88.1.132"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70293-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.4.432"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200407000-00026"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.03146.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-135MG"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002333"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3616"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815587877"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.04.009"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-138MG"},{"key":"e_1_3_2_15_2","first-page":"1269","article-title":"Cardiac and sympathetic activation are reduced in children with Down syndrome and sleep disordered breathing","volume":"35","author":"O\u2019Driscoll DM","year":"2012","unstructured":"O\u2019Driscoll DM, Horne RS, Davey MJ, et al. 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