{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:21Z","timestamp":1790837061930,"version":"4.1.0"},"reference-count":7,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82201301"],"award-info":[{"award-number":["82201301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"crossref","award":["2024AFB615"],"award-info":[{"award-number":["2024AFB615"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP), particularly the type 2 endotype driven by IL-4\/IL-13, remains challenging in a subset of patients refractory to surgery, allergen immunotherapy (AIT), and existing biologics. This case report describes a 29-year-old male with severe, multirefractory CRSwNP who achieved rapid and sustained remission with stapokibart (CM310), a novel anti-IL-4R\u03b1 monoclonal antibody, after failing 2 endoscopic sinus surgeries, omalizumab, and AIT. Following a regimen of 300\u2009mg every 2\u2009weeks, the patient exhibited significant olfactory improvement within 1\u2009week and near-complete anosmia resolution by week 4. At 32\u2009weeks, marked reductions in polyp burden, symptom scores (22-item Sinonasal Outcome Test (SNOT-22), Visual Analogue Scale (VAS), nasal congestion score (NCS), total symptom score (TSS)), and serum total IgE were documented. This case highlights stapokibart as a potent therapeutic option capable of inducing significant clinical response where conventional interventions have failed, supporting further investigation into IL-4R\u03b1 blockade for treatment-refractory CRSwNP.<\/jats:p>","DOI":"10.1177\/01455613261417770","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:06:50Z","timestamp":1769836010000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful Treatment with Stapokibart in a Severe Uncontrolled CRSwNP Patient: A Case of Rapid Symptom Resolution After Biologic and Surgical Failures"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1138-9618","authenticated-orcid":false,"given":"Hua","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Province Clinical Research Center for Deafness and Vertigo, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Province Clinical Research Center for Deafness and Vertigo, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha-Zhou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Province Clinical Research Center for Deafness and Vertigo, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Province Clinical Research Center for Deafness and Vertigo, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Province Clinical Research Center for Deafness and Vertigo, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.03.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-025-02151-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03651-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102076"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102467"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110721"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph18071021"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613261417770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613261417770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613261417770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:39:30Z","timestamp":1777401570000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613261417770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":7,"alternative-id":["10.1177\/01455613261417770"],"URL":"https:\/\/doi.org\/10.1177\/01455613261417770","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"article-number":"01455613261417770"}}