{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:37:03Z","timestamp":1777563423042,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Medical Innovation Project of the Science and Education Department of Fujian Provincial Health Commission","award":["(Grant No.: 2025CXA050)"],"award-info":[{"award-number":["(Grant No.: 2025CXA050)"]}]},{"name":"the National Traditional Chinese Medicine Advantage Specialty Construction Project","award":["20250042"],"award-info":[{"award-number":["20250042"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To explore the key factors influencing hearing recovery in patients with sudden sensorineural hearing loss (SSNHL) and provide a basis for clinical prognosis evaluation and individualized treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Clinical data of 164 inpatients with SSNHL at a tertiary hospital in Fujian Province from January 2022 to December 2024 were retrospectively analyzed, including basic characteristics, hearing features, examination findings, and treatment measures. Univariate analyses (Chi-square test, Kruskal-Wallis H test) and a multivariate logistic regression model were used to identify prognostic factors, and a neural network model was constructed to evaluate its predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 164 patients, 27 (16.46%) showed no response, 61 (37.20%) responded, 32 (19.51%) showed marked response, and 44 (26.83%) were cured. Univariate analysis revealed that age, length of hospital stay, degree of hearing loss, type of hearing loss, brain MRI findings, triglyceride (TG) levels, low-density lipoprotein (LDL-C) levels, and the use of glucocorticoids and batroxobin were associated with treatment outcomes (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Multivariate logistic regression indicated that TG (OR\u2009=\u20090.559,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.002) and LDL-C (OR\u2009=\u20090.352,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001) were independent risk factors, while glucocorticoid use was a protective factor (OR\u2009=\u20098.564,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.004). The neural network model exhibited good predictive performance (AUC\u2009=\u20090.889, accuracy rate 86.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Advanced age, severe hearing loss (especially total deafness), abnormal brain MRI findings, and elevated TG and LDL-C levels may lead to poor prognosis in SSNHL, while early use of glucocorticoids can improve outcomes. The neural network model can effectively evaluate patients\u2019 potential for hearing recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613261420982","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:41:39Z","timestamp":1772527299000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Hearing Recovery in Sudden Sensorineural Hearing Loss: Focus on Lipids, Glucocorticoids, and Predictive Model Performance"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4222-5213","authenticated-orcid":false,"given":"Bin","family":"Ai","sequence":"first","affiliation":[{"name":"The Third Affiliated People\u2019s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wusong","family":"Huang","sequence":"additional","affiliation":[{"name":"The Third Affiliated People\u2019s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"issue":"5","key":"e_1_3_2_2_2","first-page":"385","article-title":"Interpretation of AAO-HNSF clinical practice guideline: sudden hearing loss (update) and comparison with previous edition","volume":"34","author":"Li S","year":"2020","unstructured":"Li S, Zhang F, Yang J. 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