{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:12:45Z","timestamp":1779264765130,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Biologics are well established in treating severe chronic rhinosinusitis with nasal polyps (CRSwNP). Most patients benefit from the first chosen biologic agent, in a few cases switching biologics can be a further therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this monocentric retrospective study, patients with CRSwNP and biologic therapy were compared with respect to Sino-Nasal Outcome Test-22 (SNOT-22) score, bilateral nasal polyp score (NPS), and change in biologic agent as primary variables. Statistical analysis was performed using independent sample\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests or Welch\u2019s\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests for continuous variables and Pearson\u2019s chi-squared test for categorical data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 48 patients with CRSwNP who received biologic therapy between 2020 and 2024 were included in this study. During the course of treatment, 10 patients (20.4%) required a switch to a different biologic agent. A significant reduction in both the SNOT-22 score and NPS was observed in patients regardless of whether a biologic switch occurred, following a minimum post-treatment observation period of 6\u2009months. No significant differences in clinical outcomes were found between patients who switched biologics and those who continued with their initial agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Most patients switched from anti-immunoglobulin E or anti-IL-5 treatment to anti-IL-4\/-IL-13, with good improvement in therapy control. Notably, symptom control after switching biologics does not differ significantly from that achieved in patients who remained on their initial biologic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613261438970","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:41:48Z","timestamp":1778935308000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Switching Biologics in CRSwNP Promising? Real-World Evidence for Clinical Outcome Measures in Comparison"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1346-0480","authenticated-orcid":false,"given":"Kornmann","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Mannheim, Medical Faculty of the Ruprecht-Karls-University of Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kramer","family":"Benedikt","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Mannheim, Medical Faculty of the Ruprecht-Karls-University of Heidelberg, Germany"},{"name":"HNO-Zentrum Ettlingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rotter","family":"Nicole","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Mannheim, Medical Faculty of the Ruprecht-Karls-University of Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiz","family":"Elena","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Mannheim, Medical Faculty of the Ruprecht-Karls-University of Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scherl","family":"Claudia","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Mannheim, Medical Faculty of the Ruprecht-Karls-University of Heidelberg, Germany"},{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Medical Faculty Bielefeld, University Hospital Bielefeld, Bielefeld University, Germany"},{"name":"AI Health Innovation Cluster, Heidelberg-Mannheim Health and Life Science Alliance, Heidelberg University, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaubitzer","family":"Lena","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Mannheim, Medical Faculty of the Ruprecht-Karls-University of Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013513.pub2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12189"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4024"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.041"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-023-01273-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14809"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105523"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23234"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin22.129"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13875"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15007-022-5080-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31305"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.16499"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23466"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13226883"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08461-y"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin22.408"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2218617"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.165"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30983"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.10.016"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000519228"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.12.014"}],"container-title":["Ear, Nose &amp; 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