{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:13:32Z","timestamp":1779264812789,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Bilateral sudden sensorineural hearing loss (BSSHL) is an uncommon otologic emergency that may occur as the initial manifestation of relapsed B-cell non-Hodgkin lymphoma complicated by hyperviscosity syndrome (HVS). Systemic Bruton tyrosine kinase (BTK) inhibition can reduce IgM levels but may be insufficient to reverse cochlear dysfunction. We present a 74-year-old woman with a history of small B-cell non-Hodgkin lymphoma who developed simultaneous bilateral profound sudden hearing loss secondary to clinically presumed Waldenstr\u00f6m macroglobulinemia (WM). Serum IgM peaked at 53.21 g\/L, and fundoscopic examination showed typical hyperviscosity retinopathy. Despite four weeks of treatment with zanubrutinib, hearing showed no improvement. Bilateral intratympanic dexamethasone (IT-Dex) injections (5 mg daily for 6 consecutive days) were administered as salvage therapy.<\/jats:p>\n                  <jats:p>The patient began to perceive sound on day 3 and showed significant hearing improvement by day 6. Pure-tone average thresholds improved by 15 dB in the right ear and 20 dB in the left ear. This case demonstrates that IT-Dex injection is an effective salvage intervention for refractory HVS-related BSSHL that is unresponsive to systemic BTK inhibitor therapy. Multidisciplinary collaboration between otolaryngologists and hematologists is essential for timely diagnosis and intervention.<\/jats:p>","DOI":"10.1177\/01455613261453958","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:48:52Z","timestamp":1778957332000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intratympanic Dexamethasone Injection as Salvage Therapy for Refractory Bilateral Sudden Sensorineural Hearing Loss in Clinically Presumed Waldenstr\u00f6m Macroglobulinemia: A Case Report and Literature Review"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-2138","authenticated-orcid":false,"given":"Yuhui","family":"Deng","sequence":"first","affiliation":[{"name":"Fudan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Fudan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7373-7051","authenticated-orcid":false,"given":"Yangyang","family":"Ji","sequence":"additional","affiliation":[{"name":"Fudan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2179-5484","authenticated-orcid":false,"given":"Linglan","family":"Gu","sequence":"additional","affiliation":[{"name":"Fudan University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.05.015"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859885"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13981"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004345"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000107435"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.2484\/rcr.2006.1.77"},{"key":"e_1_3_9_8_2","first-page":"e44127","article-title":"Waldenstrom macroglobulinemia: Clinical presentation, diagnosis, and management in an elderly male","volume":"15","author":"Shahab S","year":"2023","unstructured":"Shahab S, Semerdzhiev DI, Reeves J, et al. Waldenstrom macroglobulinemia: Clinical presentation, diagnosis, and management in an elderly male. Cureus. 2023;15:e44127.","journal-title":"Cureus"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.26494"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100073424"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197911000-00051"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S424072"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/2474126420987142"},{"key":"e_1_3_9_14_2","volume-title":"Waldenstr\u00f6m macroglobulinemia with hyperviscosity: illustrative case series","author":"Ershler W","year":"2012","unstructured":"Ershler W. Waldenstr\u00f6m macroglobulinemia with hyperviscosity: illustrative case series. Relias Media; 2012."},{"issue":"16","key":"e_1_3_9_15_2","first-page":"17","article-title":"View of Waldenstrom\u2019s macroglobulinemia presenting as syncope","volume":"5","author":"Sedhom R","year":"2016","unstructured":"Sedhom R. View of Waldenstrom\u2019s macroglobulinemia presenting as syncope. 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