{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:45:31Z","timestamp":1785782731047,"version":"3.56.0"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["C202307018826"],"award-info":[{"award-number":["C202307018826"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify independent risk factors for chronic rhinosinusitis with nasal polyps (CRSwNP) and develop a clinical risk scoring system for its prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 420 patients categorized into CRSwNP and CRSsNP groups. Demographic, clinical (asthma), and hematologic parameters\u2014including blood eosinophil count (BEC) and inflammatory markers\u2014were analyzed. Subgroup stratification focused on inhalant allergen sensitization (single vs. multiple) at different BEC levels (cut-off: 0.15 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L). Independent risk factors were identified via multivariate logistic regression, and an integer-based scoring system was developed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRSwNP patients showed significantly higher BEC, asthma prevalence, and multiple sensitization rates (p &lt; 0.05). In the low-BEC population (&lt;0.15 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L), multiple inhalant sensitization\u2014but not single sensitization\u2014was associated with higher polyp incidence (p &lt; 0.05). Multivariate analysis confirmed asthma (OR = 4.914), elevated BEC (OR = 2.364), and multiple inhalant allergen sensitization (OR = 2.298) as independent risk factors. A scoring system (0\u20134 points) based on these factors demonstrated good predictive efficacy with an area under the ROC curve (AUC) of 0.770.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multiple inhalant allergen sensitization is a key independent predictor for CRSwNP, particularly in non-eosinophilic patients. The proposed scoring system provides a practical tool for early identification and intervention in high-risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01455613261462250","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:51:53Z","timestamp":1785527513000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Inhalant Allergen Sensitization as an Independent Risk Factor and Predictor for Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3357-6220","authenticated-orcid":false,"given":"Zikang","family":"Xiao","sequence":"first","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Gao","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1238673"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105523"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22994"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2025.03.014"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15679"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin22.489"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.09.019"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12577"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-024-01180-8"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040817"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.01.005"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2024.04.026"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.16064"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.016"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.11.001"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00410-w"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.961503"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.09.041"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2024.10.008"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.12515"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23527"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23416"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.02.029"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613261462250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613261462250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613261462250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:03:25Z","timestamp":1785780205000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613261462250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":23,"alternative-id":["10.1177\/01455613261462250"],"URL":"https:\/\/doi.org\/10.1177\/01455613261462250","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"article-number":"01455613261462250"}}