{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:15:37Z","timestamp":1781532937303,"version":"3.54.5"},"reference-count":5,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ear Nose Throat J"],"abstract":"<jats:p>Middle ear adenomatous neuroendocrine tumors (MEANT) are rare neoplasms frequently misdiagnosed due to their nonspecific clinical presentations. We present the case of a 25-year-old woman who reported a 2-month history of tinnitus, dizziness, and left-sided conductive hearing loss. Otoendoscopy and computed tomography revealed a well-circumscribed, vascular soft-tissue mass in the epitympanum extending to the mastoid antrum, which was subsequently managed with complete transcanal endoscopic excision. Histopathological evaluation confirmed a well-differentiated neuroendocrine tumor. A definitive diagnosis was established through comprehensive immunohistochemical profiling, demonstrating positive staining for INSM-1 and chromogranin-A, alongside a low Ki-67 proliferation index of less than 3%. Following the procedure, the patient exhibited stable hearing and no clinical or radiologic evidence of tumor recurrence over an 8-year follow-up period. Ultimately, this case highlights the critical importance of utilizing the 2022 WHO classification and immunohistochemical markers to accurately diagnose MEANT. Furthermore, it underscores a vital clinical caveat: while complete surgical excision is the definitive treatment, the tumor's established propensity for delayed recurrence mandates indefinite, long-term clinical and radiologic surveillance.<\/jats:p>","DOI":"10.1177\/01455613261462251","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:34:51Z","timestamp":1781274891000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroendocrine Tumor of the Middle Ear"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-0460","authenticated-orcid":false,"given":"Po-Hsuan","family":"Jeng","sequence":"first","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-4368","authenticated-orcid":false,"given":"Hao","family":"Yen","sequence":"additional","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-0317","authenticated-orcid":false,"given":"Tien-Ru","family":"Huang","sequence":"additional","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5515-2509","authenticated-orcid":false,"given":"Cheng-Ping","family":"Shih","sequence":"additional","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/moo.0000000000001075"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000001905"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/00034894251412369"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2026.1687587"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105465"}],"container-title":["Ear, Nose &amp; Throat Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613261462251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01455613261462251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01455613261462251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:48:29Z","timestamp":1781531309000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01455613261462251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":5,"alternative-id":["10.1177\/01455613261462251"],"URL":"https:\/\/doi.org\/10.1177\/01455613261462251","relation":{},"ISSN":["0145-5613","1942-7522"],"issn-type":[{"value":"0145-5613","type":"print"},{"value":"1942-7522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"article-number":"01455613261462251"}}