{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:03:29Z","timestamp":1777910609961,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Educ"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>Diabetes treatment has traditionally focused on correcting insulin deficiency using exogenous insulin and oral agents to enhance insulin secretion or insulin sensitivity in peripheral tissues. The more recent view of diabetes as a disease that affects multiple hormones, including insulin, has led to the development of therapies more broadly aimed at restoring glucose homeostasis by correcting abnormalities in other glucoregulatory hormones, including amylin. Patients with diabetes are deficient in both insulin and amylin, which contributes to postprandial hyperglycemia. Amylin, a neuroendocrine hormone secreted in response to nutrient intake, suppresses postprandial glucagon secretion, regulates gastric emptying, and regulates appetite. Pramlintide, a synthetic analog of the \u03b2 cell hormone amylin, regulates the rate of appearance of glucose in the bloodstream after meals through several mechanisms of action: slowing gastric emptying, preventing inappropriate postprandial secretion of glucagon, and increasing satiety. Long-term studies have demonstrated that pramlintide improves postprandial glucose fluctuations and glycosylated hemoglobin levels while reducing the amount of insulin needed and body weight. This combination of benefits associated with pramlintide makes it an attractive treatment option for patients with either type 1 or type 2 diabetes.<\/jats:p>","DOI":"10.1177\/0145721707313939","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T12:18:35Z","timestamp":1202732315000},"page":"4S-10S","source":"Crossref","is-referenced-by-count":11,"title":["Optimizing Diabetes Treatment Using an Amylin Analogue"],"prefix":"10.1177","volume":"34","author":[{"given":"Steven V.","family":"Edelman","sequence":"first","affiliation":[{"name":"University of California, San Diego, Veterans Affairs Medical Center, San Diego, California, Taking Control of Your Diabetes, Del Mar, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612013397357"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.8.1279"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1089\/15209150260007390"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/014572179902500310"},{"key":"atypb5","first-page":"493","volume":"44","year":"1993","journal-title":"Mol Pharmacol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90170-0"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.6.G946"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00110-3"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"atypb10","volume-title":"Symlin [package insert]","year":"2005"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(05)52018-0"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(94)90076-0"},{"key":"atypb13","volume-title":"Presented at: Satellite Symposium of the 34th Annual American Association of Diabetes Educators Conference"},{"key":"atypb14","volume-title":"Presented at: American Diabetes Association 65th Scientific Sessions; June 10-14, 2005"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.0013"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0042"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.784"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.4.724"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1732-4"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2003"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0589"},{"key":"atypb22","volume-title":"Presented at: American Diabetes Association 67th Scientific Sessions; June 22-26, 2007"},{"key":"atypb23","volume-title":"Presented at: American Diabetes Association 67th Scientific Sessions; June 22-26, 2007"}],"container-title":["The Diabetes Educator"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0145721707313939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0145721707313939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:01:51Z","timestamp":1777647711000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0145721707313939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":23,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1177\/0145721707313939"],"URL":"https:\/\/doi.org\/10.1177\/0145721707313939","relation":{},"ISSN":["0145-7217","1554-6063"],"issn-type":[{"value":"0145-7217","type":"print"},{"value":"1554-6063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}