{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T12:00:45Z","timestamp":1780228845258,"version":"3.54.0"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann ICRP"],"abstract":"<jats:p>The principle of microbeam radiotherapy (MRT) is the delivery of a single high-dose fraction to a large treatment area divided into several smaller fields, to reduce the treatment's overall toxicity. Since the fundamental concept of MRT was first established, a notable tissue-sparing effect (TSE) has been confirmed in a large variety of species and tissue types, although the underlying biological mechanism in this process remains unclear. By coupling high-precision MRT with an ex-vivo mouse spermatogenesis model, we demonstrated the significant testicular TSE for maintaining spermatogenesis following MRT. To our knowledge, this was the first TSE identified in reproductive tissue. Our high-precision microbeam analysis also revealed that an efficient TSE for spermatogenesis relies on the size of the non-irradiated germ stem cell pool in the irradiated testicular tissues, suggesting the involvement of stem cell migration\/competition. These findings of testicular TSE indicate that radiation infertility is not dose-dependent, but instead depends on micro-dosimetric conditions, and that the limit of the TSE is a potential threshold for radiation-induced male infertility.<\/jats:p>","DOI":"10.1177\/01466453251412161","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:25:48Z","timestamp":1779974748000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rethinking tissue reactions to radiation exposure: The tissue-sparing effect as a threshold for radiation-induced male infertility"],"prefix":"10.1177","author":[{"given":"H.","family":"Fukunaga","sequence":"first","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Prise","sequence":"additional","affiliation":[{"name":"Johnstone Cancer Research Centre, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1972.52.1.198"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12562"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE-21-00134.1"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2021.08.011"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2017.1355579"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14957.1"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48772-3"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE-19-00018.1"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041089"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-018-0444-4"},{"issue":"2","key":"e_1_3_2_12_1","first-page":"1","article-title":"The 2007 Recommendations of the International Commission on Radiological Protection","volume":"37","author":"ICRP","year":"2007","unstructured":"ICRP, 2007. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103, Ann. ICRP 37(2\u20134), 1\u2013332.","journal-title":"Ann. ICRP"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0146645315595585"},{"key":"e_1_3_2_14_1","first-page":"27","article-title":"Theorie einer methode, bisher unm\u00f6glich unanwendbar hohe dosen r\u00f6ntgenstrahlen in der tiefe des gewebes zur therapeutischen wirksamkeit zu bringen ohne schwere sch\u00e4digung des patienten, zugleich eine methode des schutzes gegen r\u00f6ntgenverbrennung \u00fcberhaupt","volume":"14","author":"K\u00f6hler A.","year":"1909","unstructured":"K\u00f6hler A., 1909. Theorie einer methode, bisher unm\u00f6glich unanwendbar hohe dosen r\u00f6ntgenstrahlen in der tiefe des gewebes zur therapeutischen wirksamkeit zu bringen ohne schwere sch\u00e4digung des patienten, zugleich eine methode des schutzes gegen r\u00f6ntgenverbrennung \u00fcberhaupt. Fortschr. Geb. 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