{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:10:09Z","timestamp":1792645809673,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> In children who depend on long\u2010term parenteral nutrition (PN), liver disease is a major complication that may lead to end\u2010stage liver failure requiring liver transplantation. <jats:italic>Methods:<\/jats:italic> This retrospective study investigated the influence of lipid emulsions on cholestasis onset in children receiving long\u2010term total parenteral nutrition (TPN) with lipids. Ten children who presented with a total of 23 episodes of cholestasis, associated in 13 cases with thrombocytopenia, were studied. <jats:italic>Results:<\/jats:italic> Changes in the lipid delivery preceded these complications in more than half the cases. The temporary decrease in lipid administration led to normalization of bilirubin in 17 episodes. Conclusions: These data suggest that lipid supply is one of the risk factors for PN\u2010associated cholestasis. The link between cholestasis and the reticuloendothelial system overload needs to be better understood. Prevention of cholestasis might include the decrease in the lipid load. When cholestasis occurs, lipid supply should be temporarily stopped, especially in the case of associated thrombocytopenia. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> 24:345\u2013350, 2000)<\/jats:p>","DOI":"10.1177\/0148607100024006345","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"345-350","source":"Crossref","is-referenced-by-count":270,"title":["Role of Lipid Emulsions in Cholestasis Associated with Long\u2010Term Parenteral Nutrition in Children"],"prefix":"10.1002","volume":"24","author":[{"given":"Virginie","family":"Colomb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Jobert\u2010Giraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lacaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Fournet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Ricour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198601000-00004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90864-9"},{"key":"e_1_2_1_4_1","first-page":"1054","article-title":"Long term parenteral nutrition in children: Liver and gallbladder disease","volume":"24","author":"Colomb V.","year":"1992","journal-title":"Transplant Proc"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90507-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1063548"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91079-W"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1981.02130310034012"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010003284"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90486-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0016-5085(81)90663-6","article-title":"Serial liver biopsies in parenteral nutrition\u2010associated cholestasis of early infancy","volume":"81","author":"Dahms BB","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.3.241"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0016-5085(82)80258-8","article-title":"Hepatic alterations during TPN in patients with inflammatory bowel disease: A possible consequence of lithocholate toxicity","volume":"82","author":"Fouin\u2010Fortunet H.","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70250-6"},{"key":"e_1_2_1_15_1","first-page":"G427","article-title":"Impaired hepatocanalicular organic anion transport in endotoxemic rats","volume":"269","author":"Roelofsen H.","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_1_16_1","first-page":"877","volume-title":"Baill\u00e8re's Clinical Gastroenterology. 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