{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:51:20Z","timestamp":1760982680931,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p><jats:italic>Background and Methods:<\/jats:italic> The administration of trace elements is thought to be needed in patients receiving long\u2010term parenteral nutrition. Recently, manganese intoxication or deposition was documented in such patients. We report two cases of manganese intoxication during intermittent parenteral nutrition including manganese. Manganese had been administered for 4 years at a frequency of one or two times per week in one case and for 5 years at a frequency of one or two times per month in the other case. Both cases showed mild symptoms with headache and dizziness. One case had mild hepatic dysfunction and the other did not. The whole\u2010blood manganese level increased in one case, but not in the other case. T1\u2010weighted magnetic resonance images revealed symmetrical high\u2010intensity areas in basal ganglia and thalamus in both cases. After the administration of manganese was stopped, these symptoms all disappeared and the magnetic resonance images abnormalities gradually improved in both patients. Mild long\u2010term manganese intoxication is thus considered to occur regardless of the frequency of using a manganese supplement. Conclusions: Patients should be carefully monitored when receiving long\u2010term parenteral nutrition including manganese, even when the manganese dose is small and the frequency of receiving a manganese supplement is low. <jats:italic>(journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>25<\/jats:bold>:95\u201399, 2001)<\/jats:p>","DOI":"10.1177\/014860710102500295","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"95-99","source":"Crossref","is-referenced-by-count":28,"title":["Manganese Intoxication During Intermittent Parenteral Nutrition: Report of Two Cases"],"prefix":"10.1002","volume":"25","author":[{"given":"Kouji","family":"Masumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiyo","family":"Suita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamanouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Ogita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Futoshi","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/ajcn\/49.3.573","article-title":"Trace element metabolism in adult patients requiring TPN","volume":"49","author":"Fleming CR","year":"1989","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03290450049024"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/ajcn\/48.5.1324","article-title":"Guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving TPN: Report of the Subcommittee on Pediatric Parenteral Nutrient requirements from the Committee on Clinical Practice Issues of The American Society for Clinical Nutrition","volume":"48","author":"Greene HL","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013002168"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607190014004428"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1909445"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.2.1410368"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90109-G"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.6.527"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1994.tb04339.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607195019004310"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050333"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90735-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719702100141"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.3.263"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050686"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(98)00074-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00289-5"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.4.551"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02482325"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199510000-00007"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90173-4"},{"key":"e_1_2_1_24_1","first-page":"193","volume-title":"Trace Substances in Environmental Health","author":"Doisy EA","year":"1972"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/014860719802200249","article-title":"Safe practices for parenteral nutrition formulations","volume":"22","author":"A.S.P.E.N. 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