{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:36:37Z","timestamp":1760920597310,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Hyperlipidemia after orthotopic liver transplant is thought to be the result of the immunosuppression therapy given postoperatively. The purpose of this study was to evaluate serum lipid levels pretransplant, 4 months, and 12 months posttransplant. <jats:italic>Methods:<\/jats:italic> A retrospective chart review of 50 patients after liver transplantation was completed. Pretransplant serum lipid levels (triglyceride, cholesterol, and high\u2010density lipoprotein [HDL]) were compared with values at 4 months and 12 months posttransplantation. Pretransplant serum lipid levels were compared using one factor analysis of variance (ANOVA) model. Values between the viral, alcohol, and cholestatic groups were compared using two\u2010factor ANOVA model. <jats:italic>Results:<\/jats:italic> Of the 50 patients (22 females, 28 males) with a mean age of 52 years (range, 16 to 69 years), all 50 had completed their 12\u2010month follow\u2010up at the time of this study. The etiology of liver disease included: viral hepatitis (21), alcohol (8), primary biliary cirrhosis and sclerosing cholangitis (7), and others (14). The protocol for immunosuppression included tacrolimus and prednisone. Mean serum triglyceride levels included: 134 mg\/dL pretransplant, 155 mg\/dL at 4 months, and 169 mg\/dL at 12 months posttransplant (p =.117). Mean total serum cholesterol levels included: 174 mg\/dL pretransplant, 165 mg\/dL at 4 months, and 163 mg\/dL at 12 months posttransplant (p =.654). Mean HDL levels included: 39 mg\/dL pretransplant, 45 mg\/dL at 4 months and 44 mg\/dL at 12 months posttransplant (p =.032). There was not a significant difference in serum lipids between the different categories of liver diseases. <jats:italic>Conclusions:<\/jats:italic> Although a significant positive effect was observed with HDL, the present data show that total serum cholesterol and triglyceride did not change significantly over time after orthotopic transplantation. This is most likely related to the type of immunosuppressive therapy given posthepatic transplantation. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>25:<\/jats:bold> 148\u2013151, 2001)<\/jats:p>","DOI":"10.1177\/0148607101025003148","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"148-151","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Tacrolimus and Prednisone on Serum Lipids After Liver Transplantation"],"prefix":"10.1002","volume":"25","author":[{"given":"James S.","family":"Scolapio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Lukens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Ukleja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1480","article-title":"Hyperlipidemia and obesity after orthotopic liver transplantation","volume":"23","author":"Munoz S.","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199201000-00021"},{"key":"e_1_2_1_4_1","first-page":"29","article-title":"Hyperlipidemia and other coronary risk factors after orthotopic liver transplantation: Pathogenesis, diagnosis and management","volume":"1","author":"Munoz S.","year":"1995","journal-title":"Liver Transpl Surg"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90517-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1681\/ASN.V71158","article-title":"Cardiovascular disease after renal transplantation","volume":"7","author":"Kasiske BL","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)64916-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500030101"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199709270-00029"},{"key":"e_1_2_1_10_1","first-page":"37","article-title":"Gastrointestinal and metabolic problems associated with immunosuppression with either CyA or FK506 in liver transplantation","volume":"22","author":"Van Thiel DH","year":"1990","journal-title":"Transplant Proc"},{"key":"e_1_2_1_11_1","first-page":"1136","article-title":"Influence of long\u2010term cyclosporine or FK506 therapy on glucose and lipid metabolism in stable liver graft recipients","volume":"27","author":"Loss M.","year":"1995","journal-title":"Transplant Proc"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1399-0012.1998.tb01082.x","article-title":"Lipoprotein abnormalities in long term stable liver and renal transplanted patients. A comparative study","volume":"12","author":"Fernandez\u2010Miranda C.","year":"1998","journal-title":"Clin Transplant"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500030409"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00535-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199610150-00011"},{"key":"e_1_2_1_16_1","first-page":"381","article-title":"Serum lipids and apolipoproteins in liver transplant recipients: A comparative study of cyclosporin A and FK 506","volume":"124","author":"Krentz AJ","year":"1994","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199405150-00020"},{"key":"e_1_2_1_18_1","first-page":"1121","article-title":"Hyperlipidemia after liver transplantation: Long term results of the FK 506\/cyclosporine a US multicenter trial","volume":"27","author":"Abouljoud MS","year":"1995","journal-title":"Transplantation Proc"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607101025003148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:14:03Z","timestamp":1760876043000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607101025003148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1177\/0148607101025003148"],"URL":"https:\/\/doi.org\/10.1177\/0148607101025003148","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}