{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:32:16Z","timestamp":1760920336259,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Long chain polyunsaturated fatty acids (LCPUFAs) such as arachidonic acid (AA) and eicosapentaenoic acid (EPA) stimulate intestinal adaptation. Prostaglandins also enhance intestinal adaptation. The purpose of this study was to determine by which eicosanoid pathway dietary arachidonic acid enhances intestinal adaptation. Cyclo\u2010oxygenase or lipoxygenase were selectively inhibited to determine whether either of them enhanced or inhibited adaptation. <jats:italic>Methods:<\/jats:italic> Sixty Sprague\u2010Dawley rats were divided into 2 groups, one receiving an 80% small bowel resection and the other receiving a sham operation. Rats were further divided into groups receiving either a placebo, a general lipoxygenase inhibitor (nordihydroguaiaretic acid [NDGA] at 40 mg\/kg per day), or a cyclo\u2010oxygenase\u20102 inhibitor (Etodolac at 3 mg\/kg per day). Rats were pair\u2010fed a diet containing 30% kcal from fat, primarily consisting of AA. <jats:italic>Results:<\/jats:italic> After 14 days, mucosal mass, protein, DNA, and disaccharidase activity were measured in the remaining small intestine. There was a significant decrease in ileal mucosal mass in rats receiving Etodolac and a significant increase in mucosal mass in the duodenum in rats receiving NDGA (both p &lt;.001). Mucosal DNA, protein, and disaccharidase data showed similar trends. <jats:italic>Conclusions:<\/jats:italic> These findings suggest that after small bowel resection, dietary arachidonic acid may facilitate the adaptation process by acting as a substrate for the synthesis of prostaglandins, and not through the derivatives of lipoxygenase such as leukotrienes or thromboxanes. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>25:275\u2010<\/jats:bold>281, 2001)<\/jats:p>","DOI":"10.1177\/0148607101025005275","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"275-281","source":"Crossref","is-referenced-by-count":10,"title":["The Role of Eicosanoids in the Process of Adaptation Following Massive Bowel Resection in the Rat"],"prefix":"10.1002","volume":"25","author":[{"given":"Kathryn A.","family":"Kollman\u2010Bauerly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah L.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric L.","family":"Lien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon A.","family":"Vanderhoof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199510000-00012"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352883"},{"key":"e_1_2_1_4_1","first-page":"830","volume-title":"Pediatric Gastrointestinal Disease\u2010Pathophysiology, Diagnosis, Management","author":"Vanderhoof JA","year":"1996"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536635"},{"key":"e_1_2_1_6_1","first-page":"59","article-title":"Influence of dietary components on intestinal adaptation after small bowel resection in rats","volume":"2","author":"Buts JP","year":"1979","journal-title":"Clin Invest Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199205000-00001"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90859-6"},{"key":"e_1_2_1_9_1","first-page":"146","article-title":"Functional compensation after small bowel resection in man","volume":"1","author":"Dowling RH","year":"1966","journal-title":"Lancet"},{"key":"e_1_2_1_10_1","first-page":"692","article-title":"Compensation by the residual intestine after intestinal resection in the rat","volume":"73","author":"Hanson WR","year":"1977","journal-title":"I. 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