{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:46:04Z","timestamp":1761155164574,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R15 NR05056"],"award-info":[{"award-number":["R15 NR05056"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Malnutrition is prevalent in elders with pressure ulcers and is associated with increased morbidity and mortality. This study compared nutritional status, assessed by the Mini Nutrition Assessment (MNA), to immune function in nursing home elders with pressure ulcers. <jats:italic>Methods:<\/jats:italic> Nutritional status was assessed in nursing home residents (&gt;65 years) with a stage II or more severe pressure ulcer. Subjects were classified as well nourished, at risk of malnutrition, or malnourished according to MNA score. Blood was drawn to assess whole blood mitogen\u2010induced lymphocyte proliferation and neutrophil respiratory burst. Delayed\u2010type hypersensitivity to 3 antigens was measured. MNA status was compared with immune parameters using the Kruskall\u2010Wallis test. <jats:italic>Results:<\/jats:italic> Of the 24 subjects (23 men, 1 woman) who completed the study protocol, only 4 (17%) were classified as well nourished, whereas 7 (29%) were at risk and 13 (54%) were malnourished according to MNA score. Whole blood lymphocyte proliferation was significantly lower in the malnourished <jats:italic>vs<\/jats:italic> at risk subjects with both pokeweed (median [25<jats:sup>th<\/jats:sup>,75<jats:sup>th<\/jats:sup> percentile], 0.6 [0.3, 0.9] <jats:italic>vs<\/jats:italic> 1.8 [1.2, 2.1] disintegrations per minute [dpm]\/cell, <jats:italic>p<\/jats:italic>&lt; .05); and concanavalin A (1.7 [0.9, 2.0] <jats:italic>vs<\/jats:italic> 2.8 [2.6, 3.9] dpm\/cell, <jats:italic>p<\/jats:italic> &lt; .05) mitogens. Neutrophil respiratory burst normalized to a young control was significantly lower in malnourished subjects <jats:italic>vs<\/jats:italic> well\u2010nourished subjects (0.8 [0.5, 0.9] <jats:italic>vs<\/jats:italic> 1.4 [1.0, 1.7], <jats:italic>p<\/jats:italic> &lt; .05). Total induration to 3 skin\u2010test antigens was 13.4\u00b1 4.6, 3.5 \u00b1 2.6, and 3.8 \u00b1 1.8 (mean \u00b1 SEM) for well\u2010nourished, at risk, and malnourished, respectively (<jats:italic>p<\/jats:italic> = .059). <jats:italic>Conclusions:<\/jats:italic> Immune function is impaired with an MNA score indicative of malnutrition in nursing home elders with pressure ulcers.<\/jats:p>","DOI":"10.1177\/0148607104028006416","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"416-422","source":"Crossref","is-referenced-by-count":22,"title":["Immune Function Is Impaired With a Mini Nutritional Assessment Score Indicative of Malnutrition in Nursing Home Elders With Pressure Ulcers"],"prefix":"10.1002","volume":"28","author":[{"given":"Jan","family":"Hudgens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobbi","family":"Langkamp\u2010Henken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce K.","family":"Stechmiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli A.","family":"Herrlinger\u2010Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Carmelo","family":"Nieves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-6712.1999.tb00526.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1986.tb03411.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(98)00171-3"},{"key":"e_1_2_6_5_1","first-page":"282","article-title":"MNA predictive value in the follow\u2010up of geriatric patients","volume":"7","author":"Donini LM","year":"2003","journal-title":"J Nutr Health Aging."},{"key":"e_1_2_6_6_1","first-page":"134","article-title":"Reliability of the mini nutritional assessment (MNA) in institutionalized elderly people","volume":"6","author":"Bleda MJ","year":"2002","journal-title":"J Nutr Health Aging."},{"key":"e_1_2_6_7_1","first-page":"15","article-title":"Mini Nutritional Assessment: a practical assessment tool for grading the nutritional state of elderly patients","author":"Guigoz Y","year":"1994","journal-title":"Facts Res Gerontol."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/30.3.221"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601266"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1995.tb01523.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199522240-00011"},{"key":"e_1_2_6_12_1","first-page":"39","article-title":"Host\u2010defence mechanisms in surgical patients: a correlative study of the delayed hypersensitivity skin\u2010test response, granulocyte function and sepsis","volume":"28","author":"Christou NV","year":"1985","journal-title":"Can J Surg."},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"Association of lack of mitogen\u2010induced lymphocyte proliferation with increased mortality in the elderly","volume":"1","author":"Murasko DM","year":"1988","journal-title":"Aging Immunol Infect Dis."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1981.tb02376.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(98)00156-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(86)90138-7"},{"key":"e_1_2_6_17_1","unstructured":"Nestle Nutrition Services.MNA Mini Nutritional Assessment [Nestle Web site]. Available at:http:\/\/www.mna\u2010elderly.com\/practice\/forms\/MNA_english.pdf. Accessed June 2 2004."},{"key":"e_1_2_6_18_1","first-page":"267","volume-title":"Clinical Kinesiology.","author":"Brunnstrom S","year":"1966"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(98)00036-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000062948"},{"key":"e_1_2_6_21_1","first-page":"37","article-title":"A follow\u2010up study of ulcer healing, nutrition, and life\u2010situation in elderly patients with leg ulcers","volume":"5","author":"Wissing U","year":"2001","journal-title":"J Nutr Health Aging."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065253"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/24.1.37"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324471"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.5.637"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00228-3"},{"key":"e_1_2_6_27_1","first-page":"304","article-title":"Dementia and nutrition: intervention study in institutionalized patients with Alzheimer disease","volume":"7","author":"Gil Gregorio P","year":"2003","journal-title":"J Nutr Health Aging."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/32.3.321"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.6.M366"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607104028006416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:51:24Z","timestamp":1760881884000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607104028006416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1177\/0148607104028006416"],"URL":"https:\/\/doi.org\/10.1177\/0148607104028006416","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}