{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:29:29Z","timestamp":1770290969358,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> The aim was to assess wound healing when parenteral fish\u2010oil emulsion is given to rats receiving dexamethasone. <jats:italic>Methods:<\/jats:italic> For 5 days after skin wounding, group S (control; n = 7) received saline 1 mL\/kg intraperitoneal (IP); group D (n = 7), dexamethasone 0.2 mg\/kg IP; and group DO (n = 9), dexamethasone 0.2 mg\/kg IP plus 1 mL\/kg Omegaven (Fresenius Kabi, Austria). Wound specimens were assessed for hydroxyproline level, wound depth, histology (epidermal\/dermal regeneration, granulation tissue thickness, and angiogenesis), and expression of transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) and platelet\u2010derived growth factor\u2010AA (PDGF\u2010AA). <jats:italic>Results:<\/jats:italic> Compared with D and DO specimens, controls had higher hydroxyproline (<jats:italic>p<\/jats:italic> &lt; .01), deeper wounds (<jats:italic>p<\/jats:italic> &lt; .05), and better histologic scores (<jats:italic>p<\/jats:italic> &lt; .01 angiogenesis; others <jats:italic>p<\/jats:italic>&lt; .05). There were no significant differences between the group D and DO means for hydroxyproline level, wound depth, or histologic scores (<jats:italic>p<\/jats:italic>&gt; .05 for all). Controls had higher TGF\u2010\u03b2 expression scores than the other groups (<jats:italic>p<\/jats:italic> &lt; .01 for both) and a higher PDGF\u2010AA expression score than group DO (<jats:italic>p<\/jats:italic> &lt; .01). Groups D and DO had statistically similar TGF\u2010\u03b2 scores, but group D had a higher PDGF\u2010AA score (2.71\u00b1 0.75 <jats:italic>vs<\/jats:italic> 1.55 \u00b1 0.72, respectively; <jats:italic>p<\/jats:italic> &lt; .05). <jats:italic>Conclusions:<\/jats:italic> According to the parameters we studied, adding parenteral \u03c9\u20103 and \u03c9\u20106 fatty acids to the nutrition regimen of rats treated with dexamethasone does not seem to have adverse effects on wound healing, and effects on wound healing may not need to be considered when determining if these agents should be supplemented in nutrition support regimens.<\/jats:p>","DOI":"10.1177\/0148607107031003161","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"161-166","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Parenteral Fish\u2010Oil Emulsion (Omegaven) on Cutaneous Wound Healing in Rats Treated With Dexamethasone"],"prefix":"10.1002","volume":"31","author":[{"given":"Arzu","family":"Gercek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Konya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suheyla","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Ozgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turker","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aydin","family":"Sav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necmettin","family":"Pamir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70213-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.3.667"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70566-1"},{"key":"e_1_2_5_5_1","first-page":"71","article-title":"The role of the macrophage in wound repair: a study with hydrocortisone and antimacrophage serum","volume":"78","author":"Leibovich SJ","year":"1975","journal-title":"Am J Pathol."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12286461"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000080611.29106.9E"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607194018005417"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2187-2189.2000"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.2079"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607105029003141"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(98)00005-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.889"},{"key":"e_1_2_5_14_1","first-page":"167","article-title":"Supratentorial tumour surgery and anesthesia","volume":"32","author":"Baykan N","year":"2004","journal-title":"J Turk Anesthesiol Reanim Soc."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208273270907"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.92.6.1032"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41412.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90237-1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012216.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"e_1_2_5_21_1","volume-title":"Pocket Companion to Robbins Pathologic Basis of Disease.","author":"Robbins SL","year":"1991"},{"key":"e_1_2_5_22_1","first-page":"61","article-title":"Angiostatic effects of corticosteroid on wound healing of the rabbit ear","volume":"49","author":"Hashimoto I","year":"2002","journal-title":"J Med Invest."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.002155"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002380050019"},{"key":"e_1_2_5_25_1","first-page":"483","article-title":"Trauma and wound healing: role of the route of nutritional support","volume":"2","author":"Kiyama T","year":"2001","journal-title":"Int J Surg Invest."},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1063543"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199503010-00011"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607193017006519"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114210"},{"key":"e_1_2_5_30_1","first-page":"147","article-title":"What is new in wound healing?","volume":"34","author":"Kumar S","year":"2004","journal-title":"Turkish J Med Sci."},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(87)90005-9"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917100-00009"},{"key":"e_1_2_5_33_1","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1182\/blood.V81.7.1871.1871","article-title":"Dietary omega\u20103 fatty acids lower levels of PDGF mRNA in human mononuclear cells","volume":"81","author":"Kaminski WE","year":"1993","journal-title":"Blood"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607107031003161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607107031003161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607107031003161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:50:06Z","timestamp":1760863806000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607107031003161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1177\/0148607107031003161"],"URL":"https:\/\/doi.org\/10.1177\/0148607107031003161","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}