{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:40:45Z","timestamp":1768398045787,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["RO1\u2010HD042152"],"award-info":[{"award-number":["RO1\u2010HD042152"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Aggressive parenteral nutrition (PN) including amino acids is recommended for low\u2010birth\u2010weight infants to prevent energy and protein deficit. Their impact on acid\u2010base homeostasis has not been examined. <jats:italic>Methods:<\/jats:italic> We investigated the impact of dose and duration of parenteral amino acids, with cysteine, on acid\u2010base parameters in 122 low\u2010birth\u2010weight infants. Premature infants \u226432 weeks, \u22641850 g, and receiving parenteral amino acids at 1.5 g\/kg\/d for an extended period (&gt;24 hours), or 3 g\/kg\/d for a short (5 hour), extended (24 hour), or prolonged (3\u20135 days) duration were included in the study. Data were obtained at age 0\u20133 days (n = 43) or, when clinically stable, age 3\u20135 days (n = 49). Data from 30 infants, matched for birth weight and gestational age, receiving PN during the first 5 days after birth were also obtained. Acidosis was defined as pH &lt;7.25. <jats:italic>Results:<\/jats:italic> Acidosis was evident in all infants between 2 and 5 days after birth. Infants with large patent ductus arteriosus (PDA) exhibited significantly (<jats:italic>p<\/jats:italic> &lt; .05) lower pH early, had higher blood urea nitrogen levels (26 \u00b1 9 <jats:italic>vs<\/jats:italic> 18 + 8 mg\/dL; <jats:italic>p<\/jats:italic> &lt; .05), and had greater weight loss (\u223c17% of birth weight) when compared with infants without PDA. Gestational age, weight loss, and patent ductus arteriosus accounted for 65% of variance in acidosis. <jats:italic>Conclusions:<\/jats:italic> Low\u2010birth\u2010weight infants develop metabolic acidosis between 2 and 5 days after birth, irrespective of dose and duration of parenteral amino acid administration. Careful management of parenteral fluids and comorbidities may lower the incidence of acidosis and promote protein accretion.<\/jats:p>","DOI":"10.1177\/0148607107031004278","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"278-283","source":"Crossref","is-referenced-by-count":38,"title":["Parenteral Amino Acid and Metabolic Acidosis in Premature Infants"],"prefix":"10.1002","volume":"31","author":[{"given":"Pushkaraj","family":"Jadhav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhu S.","family":"Parimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish C.","family":"Kalhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb00844.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.5.986"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.1.e1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.270"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.83.3.F215"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000160434.69916.34"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(02)00007-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2001.0061"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200301000-00008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70014-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.05.038"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2002.tb07596.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197211092871901"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000185130.90205.1f"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00274.2005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.01.022"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.3.617"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(02)00042-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211294"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607107031004278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607107031004278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607107031004278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:48:58Z","timestamp":1760878138000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607107031004278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1177\/0148607107031004278"],"URL":"https:\/\/doi.org\/10.1177\/0148607107031004278","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}