{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:37:15Z","timestamp":1760920635820,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T00:00:00Z","timestamp":1257379200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Catheter\u2010related sepsis is the most frequent complication in patients receiving home parenteral nutrition (HPN) for short bowel syndrome (SBS). A low\u2010grade systemic inflammatory state and an altered mucosal immune response, as well as diminished intestinal barrier function have been characterized in these patients. The possibility of systemic immunocompromise has only recently been suggested. <jats:italic>Case Description:<\/jats:italic> A 45\u2010year\u2010old female with traumatic SBS was admitted for possible catheter\u2010related sepsis. She was asplenic and had insulin\u2010dependent diabetes mellitus as a result of a pancreatic resection. A large skin ulceration was present on her left calf, which appeared unusual for a disseminated bacterial infection. Chest x\u2010ray and computed tomography scan revealed multiple subpleural pulmonary infiltrates consistent with bacterial or fungal dissemination. Blood cultures from the port system and from the peripheral blood grew <jats:italic>Staphylococcus haemolyticus<\/jats:italic> and <jats:italic>Fusarium oxysporum<\/jats:italic>. The port system was removed, and flucloxacillin and voriconazole were given for 33 and 35 days, respectively. Clinical signs of disseminated sepsis resolved slowly. Bone marrow biopsy ruled out primary hematologic disease. <jats:italic>Conclusions:<\/jats:italic> (1) Catheter\u2010related sepsis in patients on HPN is usually caused by Gram\u2010positive or Gram\u2010negative bacteria or by <jats:italic>Candida<\/jats:italic> species. Identification of molds in blood cultures strongly suggests <jats:italic>Fusarium<\/jats:italic> species, which should be treated appropriately with voriconazole or amphotericin B. (2) HPN and SBS aggravated by asplenism and diabetes mellitus can cause severe immunocompromise. (3) Fusaria have a strong tendency to persist or reappear after bone marrow transplantation, which is therefore relatively contraindicated in these patients.<\/jats:p>","DOI":"10.1177\/0148607109346321","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T16:32:02Z","timestamp":1257438722000},"page":"717-720","source":"Crossref","is-referenced-by-count":9,"title":["How Immunocompromised Are Short Bowel Patients Receiving Home Parenteral Nutrition? Apropos a Case of Disseminated <i>Fusarium Oxysporum<\/i> Sepsis"],"prefix":"10.1002","volume":"33","author":[{"given":"Christoph","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gregor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Lamprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00326-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02482217"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2005.05.011"},{"key":"e_1_2_6_6_1","first-page":"G139","volume":"294","year":"2008","journal-title":"Am J Physiol"},{"key":"e_1_2_6_7_1","first-page":"G84","volume":"292","year":"2007","journal-title":"Am J Physiol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"R402","DOI":"10.1152\/ajpcell.00228.2007","volume":"294","year":"2008","journal-title":"Am J Physiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2006.06.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00014-07"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/342328"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200412000-00004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/367933"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200201243460403"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1470-9465.2004.00845.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.7.4.479"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0276"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/383319"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607109346321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607109346321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607109346321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:40:50Z","timestamp":1760877650000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607109346321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1177\/0148607109346321"],"URL":"https:\/\/doi.org\/10.1177\/0148607109346321","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}