{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:22:55Z","timestamp":1782458575829,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T00:00:00Z","timestamp":1304380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T00:00:00Z","timestamp":1304380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> In addition to its role in bone metabolism, vitamin D has important immunomodulatory and antineoplastic effects. Patients on home parenteral nutrition (HPN) receive most of their vitamin D from intravenous (IV) supplementation. Vitamin D deficiency is common in the general population, and the adequacy of vitamin D supplementation in HPN patients is unclear. The purpose of this study is to determine the vitamin D status of patients on HPN. <jats:italic>Methods:<\/jats:italic> Consecutive patients seen in a regional home nutrition program had their oral and IV vitamin D intakes determined. Plasma 25\u2010hydroxyvitamin D levels were measured in all patients. Intake of calcium, magnesium, and phosphate were also determined. <jats:italic>Results:<\/jats:italic> The mean 25\u2010hydroxyvitamin D level in 22 patients receiving HPN for a mean of 33.5 months (range, 1\u2013177) was 42 nmol\/L. Vitamin D deficiency was present in 15 (68%) patients and vitamin D insufficiency in 6 (27%) patients. The mean dietary vitamin D intake was 79.5 IU per day, while the mean IV supplementation was 166 IU per day. <jats:italic>Conclusions:<\/jats:italic> In this study of a regional Canadian HPN program, there was a high prevalence of vitamin D deficiency\/insufficiency affecting virtually all patients. All patients receiving HPN should be supplemented with vitamin D and have their 25\u2010hydroxyvitamin D levels monitored. Further studies are required to determine optimal methods and dosing of vitamin D replacement using oral supplements or ultraviolet light therapy.<\/jats:p>","DOI":"10.1177\/0148607110381269","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T21:00:35Z","timestamp":1304456435000},"page":"499-504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Vitamin D Deficiency in Patients Receiving Home Parenteral Nutrition"],"prefix":"10.1002","volume":"35","author":[{"given":"Patti","family":"Thomson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R.","family":"Duerksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.105"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.12.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0138"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607109349061"},{"key":"e_1_2_7_7_1","first-page":"33","article-title":"Improving the measurement of 25\u2010hydroxyvitamin D","volume":"26","author":"Wootton AM","year":"2005","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.040683"},{"key":"e_1_2_7_9_1","unstructured":"Canadian nutrient file for vitamin D content of foods.http:\/\/www.hc\u2010sc.gc.ca\/fn\u2010an\/nutrition\/fiche\u2010nutri\u2010data\/cnf_downloads\u2010telechargement_fcen\u2010eng.php. 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