{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:07:31Z","timestamp":1791425251927,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T00:00:00Z","timestamp":1314230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T00:00:00Z","timestamp":1314230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : Bis(2\u2010ethylhexyl)phthalate (or DEHP) is widely used in polyvinyl chloride (PVC) tubings for its good plasticizing properties. Because it is not covalently bound to the plastic matrix, it is able to escape from PVC during the infusion of the lipid emulsions used in parenteral nutrition (PN). This creates a vector through which it can enter into contact with the patient via the nutrition admixtures infused. This study was designed to assess the potential role of the type of lipids used in PN admixtures on the quantity of DEHP leached out from PVC\u2010based tubings.\n                    <jats:italic>Methods<\/jats:italic>\n                    : PVC\u2010based infusion lines, 6 commercially available lipid emulsions, and their oil base components were left in direct contact, and the amount of DEHP leached was measured by liquid chromatography.\n                    <jats:italic>Results<\/jats:italic>\n                    : After a 24\u2010hour exposure period, DEHP migration varied significantly (\n                    <jats:italic>P<\/jats:italic>\n                    = .0000152) according to lipid type. The olive oil\u2013based emulsion Clinoleic leached the most DEHP (65.8 \u00b5g\/mL intravenous fat emulsion), followed by the fish oil\u2013based emulsion Omegaven (37.8 \u00b5g\/mL). The soybean oil\u2013based emulsions Intralipid, Medialipide, Lipidem, and Structolipid showed comparable performances, with DEHP leaching rates into the emulsion measured at 27.3, 27.8, 23.6, and 19.6 \u00b5g\/mL, respectively. Results from the same experiments run on pure\u2010form oils (soybean oil, olive oil, coconut oil, and cod liver oil) confirmed the influence of lipid type on DEHP leaching.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : The major DEHP leaching caused by olive oil\u2013based emulsions raises cause for concern because DEHP presents distinctive toxic effects, including an increased risk of cholestasis.\n                  <\/jats:p>","DOI":"10.1177\/0148607111414021","type":"journal-article","created":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T22:53:08Z","timestamp":1314312788000},"page":"770-775","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Influence of Lipid Type on Bis (2\u2010ethylhexyl)phthalate (DEHP) Leaching From Infusion Line Sets in Parenteral Nutrition"],"prefix":"10.1002","volume":"35","author":[{"given":"Sandrine","family":"Bagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9rang\u00e8re","family":"Dessaigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bourdeaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Bouteloup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Etienne","family":"Bazin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Chopineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Sautou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,25]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Safety Assessment of Di(2\u2010ethylhexyl)phthlate (DEHP) Release From Medical Devices","author":"US Food and Drug Administration (FDA)","year":"2001"},{"key":"e_1_2_8_3_1","volume-title":"EAP on DEHP in Medical Devices MDB Report: An Exposure and Toxicity Assessment","author":"Hinberg I","year":"2002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2007.07.011"},{"key":"e_1_2_8_5_1","volume-title":"Preliminary Report on the Safety of Medical Devices Containing DEHP\u2010Plasticized PVC or Other Plasticizers on Neonates and Other Groups Possibly at Risk","author":"Scientific Committee on Emerging and Newly Identified Health Risks","year":"2008"},{"key":"e_1_2_8_6_1","volume-title":"Opinion on the Results of a Second Risk Assessment of Bis(2\u2010ethylhexyl) phthalate (DEHP)","author":"Scientific Committee on Toxicity, Ecotoxicity and the Environment","year":"2004"},{"key":"e_1_2_8_7_1","volume-title":"Expert Panel Re\u2010evaluation of DEHP: Meeting Summary, October 14 2005","author":"Center for the Evaluation of Risks to Human Reproduction","year":"2000"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.19249"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607102026005305"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb00864.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318164d933"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00335-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.2.182"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2003.12.018"},{"key":"e_1_2_8_15_1","volume-title":"European Union Risk Assessment Report for Bis(2\u2010ethylhexyl) phthalate","author":"European Chemicals Bureau (ECB)","year":"2006"},{"key":"e_1_2_8_16_1","unstructured":"R Causse T. 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