{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:40:35Z","timestamp":1760920835446,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,30]],"date-time":"2011-10-30T00:00:00Z","timestamp":1319932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,10,30]],"date-time":"2011-10-30T00:00:00Z","timestamp":1319932800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["96\u20102628\u2010B\u2010006\u2010038\u2010MY3"],"award-info":[{"award-number":["96\u20102628\u2010B\u2010006\u2010038\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Iron intoxication causes acute nephrotoxicity in animals and humans. Sesame oil, a healthful food, increases resistance to lipid peroxidation and protects against multiple organ injury in various animal models. The authors examined the prophylactic and therapeutic effects of a subcutaneous injection of sesame oil against iron\u2010induced acute renal injury in mice. <jats:italic>Methods:<\/jats:italic> Iron intoxication in mice was induced with an intraperitoneal injection (2 mg\/kg) of ferric\u2010nitrilotriacetate (Fe\u2010NTA). Various doses of sesame oil (0, 1, 2, and 4 mL\/kg, subcutaneously) were given immediately after (prophylactic) or 30 minutes after (therapeutic) the Fe\u2010NTA injection. Renal injury was assessed by the rise in serum blood urea nitrogen (BUN) and creatinine (CRE) levels 3 hours after the Fe\u2010NTA injection. <jats:italic>Results:<\/jats:italic> One hour after the Fe\u2010NTA injection, serum BUN and CRE levels were significantly higher in Fe\u2010NTA\u2010treated mice than in saline\u2010treated controls; 3 and 6 hours after the Fe\u2010NTA injection, they were dose\u2010dependently and significantly lower in all sesame oil\u2013treated groups than in the group treated only with Fe\u2010NTA and saline. <jats:italic>Conclusion:<\/jats:italic> A subcutaneous injection of sesame oil had both prophylactic and therapeutic effects against iron\u2010induced acute renal injury in mice.<\/jats:p>","DOI":"10.1177\/0148607111415530","type":"journal-article","created":{"date-parts":[[2011,10,30]],"date-time":"2011-10-30T20:32:59Z","timestamp":1320006779000},"page":"344-348","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prophylactic and Therapeutic Effects of a Subcutaneous Injection of Sesame Oil Against Iron\u2010Induced Acute Renal Injury in Mice"],"prefix":"10.1002","volume":"36","author":[{"given":"Ya\u2010Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se\u2010Ping","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Yi","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Yie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800017200"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100371"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00623-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.7.1231"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060828.x"},{"key":"e_1_2_6_7_1","first-page":"731","article-title":"The role of metals in neurodegenerative diseases","volume":"46","author":"Sayre LM","year":"2000","journal-title":"Cell Mol Biol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00608.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.03.015"},{"key":"e_1_2_6_10_1","first-page":"354","article-title":"Effects of iron overload on the immune system","volume":"30","author":"Walker EM","year":"2000","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480540903130633"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.07.015"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00648.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00716.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.3.343"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000164"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh565"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-56599"},{"key":"e_1_2_6_19_1","first-page":"1","article-title":"Multifunctional gift from nature","volume":"18","author":"Sugano M","year":"1993","journal-title":"J Chin Nutr Soc"},{"volume-title":"Herbs: An Indexed Bibliography 1971\u20101980. 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