{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:33:21Z","timestamp":1793694801517,"version":"4.5.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Successful small intestinal (SI) adaptation following surgical resection is essential for optimizing newborn growth and development, but the potential for adaptation is unknown. The authors developed an SI resection model in neonatal piglets supported by intravenous and enteral nutrition. <jats:italic>Methods<\/jats:italic>: Piglets (n = 33, 12\u201313 days old) were randomized to 80% SI resection with parenteral nutrition feeding (R\u2010PN), 80% SI resection with PN + enteral feeding (R\u2010EN), or sham SI transection with PN + enteral feeding (sham\u2010EN). In resected pigs, the distal 100 cm of ileum (residual SI) and 30 cm of proximal SI were left intact. All pigs received parenteral nutrition postsurgery. Enteral nutrition piglets received continuous gastric infusion of elemental diet from day 3 (40:60 parenteral nutrition:enteral nutrition). Piglets were killed 4, 6, or 10 days postsurgery. <jats:italic>Results:<\/jats:italic> By 10 days, R\u2010EN piglets had longer residual SI than R\u2010PN and sham\u2010EN pigs (<jats:italic>P<\/jats:italic> &lt; .05). At days 6 and 10, R\u2010EN piglets had greater weight per length of intact SI (<jats:italic>P<\/jats:italic> &lt; .05) and isolated mucosa (<jats:italic>P<\/jats:italic> &lt; .05) compared to other groups. Greater gut weight in R\u2010EN piglets was facilitated by a greater cellular proliferation index (<jats:italic>P<\/jats:italic> &lt; .01) by 4 days compared to other groups and greater overall ornithine decarboxylase activity vs R\u2010PN piglets (<jats:italic>P<\/jats:italic> &lt; .05). <jats:italic>Conclusions<\/jats:italic>: This new model demonstrated profound SI adaptation, initiated early postsurgery by polyamine synthesis and crypt cell proliferation and only in response to enteral feeding. These changes translated to greater gut mass and length within days, likely improving functional capacity long term.<\/jats:p>","DOI":"10.1177\/0148607111417447","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T21:25:28Z","timestamp":1324502728000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Enteral Feeding Induces Early Intestinal Adaptation in a Parenterally Fed Neonatal Piglet Model of Short Bowel Syndrome"],"prefix":"10.1002","volume":"36","author":[{"given":"M. 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