{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:34:55Z","timestamp":1790235295466,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T00:00:00Z","timestamp":1326326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T00:00:00Z","timestamp":1326326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>: The objectives were to determine concentrations of calcium chloride (CaCl) and sodium phosphate (NaPhos) that can be safely added to TrophAmine\u2010based parenteral nutrition (PN) and to measure aluminum (Al) concentrations in PN solutions containing CaCl and NaPhos vs those containing calcium gluconate (CaGlu) and potassium phosphate (KPhos). <jats:italic>Methods<\/jats:italic>: In study A, PN solutions containing varying amounts of TrophAmine, CaCl, and NaPhos were compounded and then evaluated visually for precipitation. In study B, Al concentrations were measured in PN solutions containing CaCl and NaPhos (S1), CaGlu and NaPhos (S2), or CaGlu and KPhos (S3). <jats:italic>Results<\/jats:italic>: Study A showed that a maximum phosphorus concentration of 15 mmol\/L could be added to a solution containing 12.5 mmol\/L of calcium without evidence of precipitation when the amino acid (AA) concentration reached \u22653 g\/dL (3%). In study B, the mean (range) Al concentrations were S1 = 2.2 (1.9\u20132.4), S2 = 8.5 (7.8\u20139.3), and S3 = 11.7 (10.8\u201312.2) \u00b5mol\/L (means of 6.0, 22.9, and 31.5 micrograms\/dL, respectively). <jats:italic>Conclusions<\/jats:italic>: The data can provide a guide for compounding neonatal PN solutions containing TrophAmine, CaCl, and NaPhos. More studies are needed to determine the long\u2010term effects of substituting CaCl for CaGlu in PN solutions for neonates. Substituting CaCl and NaPhos for CaGlu and KPhos significantly decreases Al concentrations in PN and potential Al exposure of neonatal patients.<\/jats:p>","DOI":"10.1177\/0148607111420154","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T02:07:19Z","timestamp":1326420439000},"page":"470-475","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Calcium Chloride and Sodium Phosphate in Neonatal Parenteral Nutrition Containing TrophAmine"],"prefix":"10.1002","volume":"36","author":[{"given":"Evelyn A.","family":"Migaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Melhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J.","family":"Dewar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Huston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705293362203"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0783"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607102026006382"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"673","article-title":"Compatibility of calcium chloride and calcium gluconate with sodium phosphate in a mixed TPN solution","volume":"37","author":"Henry RS","year":"1980","journal-title":"Am J Hosp Pharm"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"244","article-title":"Electrolyte compatibility in a synthetic amino acid hyperalimentation solution","volume":"31","author":"Kaminski MV","year":"1974","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_7_7_1","first-page":"49","article-title":"Calcium and phosphorus compatibility in parenteral nutrition solutions for neonates","volume":"39","author":"Eggert LD","year":"1982","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607191015006608"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070138"},{"issue":"3","key":"e_1_2_7_10_1","first-page":"163","article-title":"Laser particle analysis of calcium phosphate precipitate in neonatal TPN admixtures","volume":"1","author":"Hoie EB","year":"1996","journal-title":"J Pediatr Pharm Pract"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"88","article-title":"Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine","volume":"43","author":"Fitzgerald KA","year":"1986","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110374615"},{"key":"e_1_2_7_13_1","first-page":"4103","article-title":"Aluminum in large and small volume parenterals used in total parenteral nutrition","volume":"65","author":"Food and Drug Administration","year":"2000","journal-title":"Fed Reg"},{"key":"e_1_2_7_14_1","first-page":"70691","article-title":"Aluminum in large and small volume parenterals used in total parenteral nutrition; 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