{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:58:30Z","timestamp":1762505910581,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007658","name":"Baxter Healthcare Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: For 40 years, parenteral nutrition (PN) has provided therapeutic benefits to patients unable to receive oral\/enteral nutrition. Very limited published evidence exists to describe modern PN practices or characteristics of patients receiving PN. The aim of this article was to describe the characteristics of hospitalized patients receiving PN in 196 U.S. hospitals to define patient groups at risk for PN\u2010related complications. This will provide researchers a baseline understanding about who is receiving hospital\u2010based PN to maximize generalizability and validity of future research. <jats:italic>Methods<\/jats:italic>: Claims data from the Premier Perspective database, the largest inpatient clinical database in the United States, were used to evaluate hospital\u2010based PN practices. Data gathered between January 2005 and December 2007 included a total of 106,374 patients receiving PN. A total of 68,984 adults (age \u226518 years), 34,307 infants (age &lt;1 year), and 3083 pediatric patients (age 1\u201317 years) were evaluated. Key variables such as admitting diagnosis, infection rates, in\u2010hospital mortality, and costs were extracted. <jats:italic>Results<\/jats:italic>: Hospitalized patients requiring PN in the United States are older and more often white than the overall hospitalized population. Hospitalized PN patients are more likely to be admitted emergently and have a higher severity of illness. Bloodstream infection rates in adult PN patients (25.5%) were considerably higher than in pediatric (14.7%) or neonatal patients (1.7%) receiving PN. <jats:italic>Conclusions<\/jats:italic>: These findings are the first large\u2010scale description of \u201creal\u2010world\u201d hospital\u2010based PN practices in the United States, helping set a baseline for future PN research.<\/jats:p>","DOI":"10.1177\/0148607112444448","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T20:55:44Z","timestamp":1334955344000},"page":"56-67","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Characteristics and Current Practice of Parenteral Nutrition in Hospitalized Patients"],"prefix":"10.1002","volume":"37","author":[{"given":"Paul E.","family":"Wischmeyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Weitzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Mercaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Zaloga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Hise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pontes\u2010Arruda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Turpin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607109335234"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.04.024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102662"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2146-z"},{"key":"e_1_2_8_6_1","unstructured":"Trial of supplemental parenteral nutrition in under and over weight critically ill patients (TOP\u2010UP). NCT01206166.http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01206166?term=NCT01206166&rank=1. Accessed December 4 2011."},{"key":"e_1_2_8_7_1","unstructured":"Efficacy and mechanisms of GLN dipeptide in the SICU (GLND). NCT00248638.http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00248638?term=NCT00248638&rank=1. Accessed December 4 2011."},{"key":"e_1_2_8_8_1","unstructured":"The effects of early parenteral nutrition compared to standard care on 60 day landmark mortality in the critically ill patient: a level I randomised controlled trial. ACTRN12605000704695.http:\/\/www.anzctr.org.au\/trial_view.aspx?ID=863. Accessed December 4 2011."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.06.006"},{"key":"e_1_2_8_10_1","article-title":"Methods to identify and compare parenteral nutrition administered from hospital\u2010compounded and premixed multichamber bags in a retrospective hospital claims database","author":"Mercaldi CJ","year":"2011","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111414714"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.10.007"},{"issue":"8","key":"e_1_2_8_13_1","first-page":"243","article-title":"Vital signs: central line\u2013associated blood stream infections\u2014United States, 2001, 2008, and 2009","volume":"60","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32830f1fd1"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607112444448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607112444448","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607112444448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:28:17Z","timestamp":1760880497000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607112444448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,20]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1177\/0148607112444448"],"URL":"https:\/\/doi.org\/10.1177\/0148607112444448","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[2012,4,20]]}}}