{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:31:22Z","timestamp":1763987482347,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99\u20132314\u2010B\u2010006\u2010031\u2010MY3","NSC 99\u20132221\u2010E\u2010006\u2010064\u2010MY3"],"award-info":[{"award-number":["NSC 99\u20132314\u2010B\u2010006\u2010031\u2010MY3","NSC 99\u20132221\u2010E\u2010006\u2010064\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: The chemotherapeutic drug oxaliplatin causes sinusoidal obstruction syndrome (SOS), which is analogous to that of monocrotaline\u2010induced SOS. Sesame oil is a nutrient\u2010rich antioxidant in alternative medicine. It contains phenol, sesamin, sesamol, and sesamolin, all of which contribute to its antioxidant property. The authors investigated the therapeutic effect of oral sesame oil against monocrotaline\u2010induced SOS in rats. <jats:italic>Methods<\/jats:italic>: Male Sprague\u2010Dawley rats were gavaged with monocrotaline (90 mg\/kg) to induce SOS. Control rats were treated with saline only at 0 and 24 hours. Sesame oil (0.5, 1, 2, or 4 mL\/kg, orally) was given 24 hours after monocrotaline in rats. Blood samples were collected at 24 and 48 hours after monocrotaline was given to assess the level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Histopathology was also assessed 48 hours after monocrotaline was given. <jats:italic>Results<\/jats:italic>: AST and ALT were significantly higher in monocrotaline\u2010treated rats than in control rats. Oral sesame oil did not decrease AST and ALT in monocrotaline\u2010treated rats. In addition, liver pathology revealed that oral sesame oil had no therapeutic effect against SOS. <jats:italic>Conclusion<\/jats:italic>: Oral sesame oil is therapeutically ineffectual against monocrotaline\u2010induced SOS.<\/jats:p>","DOI":"10.1177\/0148607112445795","type":"journal-article","created":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T20:49:28Z","timestamp":1335646168000},"page":"129-133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic Oral Sesame Oil Is Ineffectual Against Monocrotaline\u2010Induced Sinusoidal Obstruction Syndrome in 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