{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:47Z","timestamp":1792084127452,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: To evaluate the effect of slow vs rapid rates of advancement of enteral feed volumes on the clinical outcomes in preterm infants with 750\u20131250 g birth weight. <jats:italic>Study Design<\/jats:italic>: A total of 92 stable neonates 750\u20131250 g and gestational age &lt;32 weeks were randomly allocated to enteral feeding advancement of 20 mL\/kg\/d (n = 46) or 30 mL\/kg\/d (n = 46). The primary outcome was days to reach full enteral feeding, defined as 180 mL\/kg\/d. Secondary outcomes included rates of necrotizing enterocolitis (NEC) and culture\u2010proven sepsis, days of parenteral nutrition (PN), length of hospital stay, and growth end points. <jats:italic>Results<\/jats:italic>: Neonates in the rapid\u2010feeding advancement group achieved full enteral volume of feedings earlier than the slower advancement group. They received significantly fewer days of PN, exhibited a shorter time to regain birth weight, and had a shorter duration of hospital stay. The incidence of NEC and the number of episodes of feeding intolerance were not significantly different between the groups, whereas the incidence of culture\u2010proven late\u2010onset sepsis was significantly less in infants receiving a rapid feeding advancement. Excluding infants who were small for gestational age at birth, the incidence of extrauterine growth restriction was significantly reduced in the rapid\u2010advancement group at 28 days and at hospital discharge. <jats:italic>Conclusion<\/jats:italic>: Rapid enteral feeding advancements in 750\u20131250 g birth weight infants reduce the time to reach full enteral feeding and the use of PN administration. Rapid\u2010advancement enteral feed also decreases extrauterine growth restriction with improved short\u2010term outcomes for these high\u2010risk infants.<\/jats:p>","DOI":"10.1177\/0148607112449482","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T10:30:27Z","timestamp":1338892227000},"page":"223-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":81,"title":["Randomized Controlled Trial of Slow vs Rapid Enteral Feeding Advancements on the Clinical Outcomes of Preterm Infants With Birth Weight 750\u20131250 g"],"prefix":"10.1002","volume":"37","author":[{"given":"Belma Saygili","family":"Karagol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Zenciroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurullah","family":"Okumus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Polin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,4]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1203\/00006450-200301000-00002","article-title":"Nutrient requirements in preterm infants","volume":"53","author":"Cooke RJ","year":"2003","journal-title":"Pediatr 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