{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:31:14Z","timestamp":1790281874584,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Patients with intestinal failure and short bowel syndrome usually require chronic parenteral nutrition (PN). PN is associated with risks, including infections, vascular thrombosis, and liver disease. PN\u2010associated liver disease (PNALD) can progress from steatosis to chronic hepatitis and ultimately to cirrhosis. The etiology of PNALD is not completely understood. Therapies for PNALD include carbohydrate or lipid calorie reduction, antibiotics, or the use of ursodeoxycholic acid. When these efforts fail, therapeutic options are limited and liver transplantation may be required. The transition from a soybean\u2010 to a fish oil\u2013based lipid formulation, such as the \u03c9\u20103 parenteral lipid formulation (Omegaven), has shown a dramatic reversal of PNALD within the pediatric population. This is the first report of a PN\u2010dependent adult in the United States complicated by PNALD and hepatic failure who had improvement of liver disease with an \u03c9\u20103 fish oil\u2013based parenteral formulation.<\/jats:p>","DOI":"10.1177\/0148607112450301","type":"journal-article","created":{"date-parts":[[2012,6,9]],"date-time":"2012-06-09T00:37:34Z","timestamp":1339202254000},"page":"274-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":68,"title":["Reversal of Parenteral Nutrition\u2013Associated Liver Disease With a Fish Oil\u2013Based Lipid Emulsion (Omegaven) in an Adult Dependent on Home Parenteral Nutrition"],"prefix":"10.1002","volume":"37","author":[{"given":"David L.","family":"Burns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90321-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005628121546"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"1","article-title":"Abnormalities of liver function and hepatic damage associated with total parenteral nutrition","volume":"7","author":"Freund HR","year":"1991","journal-title":"Nutrition"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710202600512"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-001-0154-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00232-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-8586(99)70015-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1998.tb01122.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1989.tb09757.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80346-0"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"30","article-title":"Chronic cholestasis and macronutrient excess in patients treated with prolonged parenteral nutrition","volume":"8","author":"Messing B","year":"1992","journal-title":"Nutrition"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780577"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1999.12.4.549"},{"issue":"3","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jpeds.2004.05.038","article-title":"Ursodeoxycholic acid (UDCA) therapy in very\u2010low\u2010birth\u2010weight infants with parenteral nutrition\u2013associated cholestasis","volume":"145","author":"Chen CY","year":"2004","journal-title":"J Pediatr"},{"issue":"11","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1345\/aph.1K229","article-title":"Ursodiol in patients with parenteral nutrition\u2013associated cholestasis","volume":"41","author":"San Luis VA","year":"2007","journal-title":"Ann Pharmacother"},{"issue":"3","key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/SLA.0b013e3181b36657","article-title":"Parenteral fish oil improves outcomes in patients with parenteral nutrition\u2013associated liver injury","volume":"250","author":"Puder M","year":"2009","journal-title":"Ann Surg"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2662"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.10.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2248"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318182c8f6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00233-5"},{"issue":"2","key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1164\/ajrccm.155.2.9032187","article-title":"Impact of arachidonic versus eicosapentaenoic acid on exotonin\u2010induced lung vascular leakage: relation to 4\u2010series versus 5\u2010series leukotriene generation","volume":"155","author":"Grimminger F","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.5.1171"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21626"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283394879"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0950fje"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607109332773"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32834670eb"},{"issue":"1","key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11596-009-0107-3","article-title":"Regulation of omega\u20103 fish oil emulsion on the SIRS during the initial stage of severe acute pancreatitis","volume":"29","author":"Xiong J","year":"2009","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108316189"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0591-5"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(11)60011-0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90507-2"},{"issue":"4","key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/archsurg.1990.01410160033006","article-title":"Liver biochemical and histological changes with graded amounts of total parenteral nutrition","volume":"125","author":"Campos AC","year":"1990","journal-title":"Arch Surg"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1991.260.1.E126"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(88)90095-9"},{"issue":"1","key":"e_1_2_7_39_1","first-page":"93","article-title":"The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man","volume":"88","author":"Kaminski DL","year":"1980","journal-title":"Surgery"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-7-200004040-00003"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110114"},{"issue":"2","key":"e_1_2_7_42_1","first-page":"190","article-title":"Total parenteral nutrition: a histopathologic analysis of the liver changes in 20 children","volume":"7","author":"Mullick FG","year":"1994","journal-title":"Mod Pathol"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1999.98925"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.019"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985070"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1241865"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90609-6"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352883"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80064-9"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181560524"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010003282"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.04.011"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.08.011"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)01009-2"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000153672.43030.75"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030326"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199902000-00008"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.08.018"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-004-1342-z"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.01.037"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1014"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181bbdf2b"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110371806"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181bbf51e"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.01.008"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607112450301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607112450301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607112450301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:47:00Z","timestamp":1760863620000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607112450301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,8]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/0148607112450301"],"URL":"https:\/\/doi.org\/10.1177\/0148607112450301","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,8]]}}}