{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:18:31Z","timestamp":1762323511292,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T00:00:00Z","timestamp":1342742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T00:00:00Z","timestamp":1342742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99\u20132314\u2010B\u2010006\u2010031\u2010MY3","NSC 99\u20132221\u2010E\u2010006\u2010064\u2010MY3"],"award-info":[{"award-number":["NSC 99\u20132314\u2010B\u2010006\u2010031\u2010MY3","NSC 99\u20132221\u2010E\u2010006\u2010064\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Sinusoidal obstruction syndrome (SOS) occurs in patients undergoing hematopoietic cell transplantation and chemotherapy. The chemotherapeutic drugs oxaliplatin and cyclophosphamide cause SOS. Sesame oil is a nutrient\u2010rich antioxidant popular in alternative medicine. It contains sesamin, sesamol, and sesamolin, all of which contribute to its antioxidant property. The authors investigated the protective effect of prophylactic sesame oil against monocrotaline\u2010induced SOS in rats. <jats:italic>Methods<\/jats:italic>: Male Sprague\u2010Dawley rats were gavaged with a single dose of sesame oil (0.5, 1, 2, or 4 mL\/kg). One hour later, those rats were gavaged with monocrotaline (90 mg\/kg) to induce SOS. Control rats were treated with saline only. Aspartate transaminase, alanine transaminase, laminin, collagen, myeloperoxidase, nitrate content, lipid peroxidation, glutathione levels, matrix metalloproteinase (MMP)\u20139, and tissue inhibitor of matrix metalloproteinases (TIMP)\u20131 were assessed 48 hours after the monocrotaline gavage. <jats:italic>Results<\/jats:italic>: All tested parameters except TIMP\u20101, laminin, collagen, and glutathione were higher in monocrotaline\u2010treated rats than in saline\u2010only\u2010treated control rats. In sesame oil\u2013treated rats, all tested parameters except TIMP\u20101, laminin, collagen, and glutathione were significantly attenuated compared with monocrotaline\u2010only\u2010treated rats. Sesame oil downregulated MMP\u20109 expression but upregulated TIMP\u20101 expression in monocrotaline\u2010only\u2010treated rats. In addition, a histological analysis of liver tissue samples showed that sesame oil showed significant protection. <jats:italic>Conclusion<\/jats:italic>: A single prophylactic dose of sesame oil protects against SOS by downregulating MMP\u20109 expression, upregulating TIMP\u20101 expression, and inhibiting oxidative stress.<\/jats:p>","DOI":"10.1177\/0148607112454299","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T09:40:49Z","timestamp":1342863649000},"page":"529-537","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Prophylactic Sesame Oil Attenuates Sinusoidal Obstruction Syndrome by Inhibiting Matrix Metalloproteinase\u20139 and Oxidative 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