{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:24:17Z","timestamp":1760984657092,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T00:00:00Z","timestamp":1358121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T00:00:00Z","timestamp":1358121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Intra\u2010abdominal desmoid tumors (IADTs) are a common complication of familial adenomatous polyposis (FAP). Treatment is not standardized for advanced disease. Medical and surgical treatments may be ineffective in preventing complications, which can cause intestinal failure. Home parenteral nutrition (HPN) can be a life\u2010saving treatment in these patients. The aim of this study was to investigate the association with HPN in FAP\u2010IADTs. <jats:italic>Methods<\/jats:italic>: A retrospective review of FAP patients with IADTs at the Cleveland Clinic (CC) between 1980 and 2009 was performed. Patients and tumor characteristics were retrieved from the CC Jagelman Registry for Inherited Neoplasms and CC HPN database. Inclusion criteria were FAP\u2010IADTs and 6\u2010month follow up at CC. Exclusion criteria were &lt;6\u2010month follow\u2010up, lack of 3\u2010dimensional lesion or sheet desmoid, and\/or incomplete medical records. Kaplan\u2010Meier curves were analyzed for HPN and non\u2010HPN groups. <jats:italic>Results<\/jats:italic>: One hundred fifty\u2010four patients were included and divided into 2 groups: HPN (n = 41, 26.6%) and non\u2010HPN (n = 113, 73.4%). The HPN group was more likely to have advanced\u2010stage disease and significantly higher incidence of chronic abdominal pain, narcotic dependency, bowel obstruction, ureteral obstruction, deep vein thrombosis, pulmonary embolism, fistulae, and sepsis (<jats:italic>P<\/jats:italic> &lt; .05). The need for HPN represented a strong predictor of mortality (5\u2010year survival HPN = 72% vs non\u2010HPN = 95%), but duration of HPN did not affect mortality. <jats:italic>Conclusion<\/jats:italic>: HPN, although a life\u2010saving treatment, is an independent poor prognostic factor associated with high morbidity and mortality.<\/jats:p>","DOI":"10.1177\/0148607112471860","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T23:55:04Z","timestamp":1358207704000},"page":"683-688","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Association Between Home Parenteral Nutrition and Patients With FAP\u2010Associated Intra\u2010Abdominal Desmoids"],"prefix":"10.1002","volume":"37","author":[{"given":"Abdullah","family":"Shatnawei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Habib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezra","family":"Steiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald 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